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Cited by 1,688Antimicrobial Resistance in StaphylococcusAntibiotic Use and ResistanceInfection Control in Healthcare

Comparison of Community- and Health Care–Associated Methicillin-Resistant <EMPH TYPE="ITAL">Staphylococcus aureus</EMPH> Infection

Naimi, Timothy S.·2003·JAMA
DOI 10.1001/jama.290.22.2976
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Abstract

Context Methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been considered a health care-associated pathogen in patients with established risk factors. However, MRSA has emerged in patients without established risk factors (community-associated MRSA). Objective To characterize epidemiological and microbiological characteristics of community-associated MRSA cases compared with health care-associated MRSA cases. Design, setting, and patients Prospective cohort study of patients with MRSA infection identified at 12 Minnesota laboratory facilities from January 1 through December 31, 2000, comparing community-associated (median age, 23 years) with health care-associated (median age, 68 years) MRSA cases. Main outcome measures Clinical infections associated with either community-associated or health care-associated MRSA, microbiological characteristics of the MRSA isolates including susceptibility testing, pulsed-field gel electrophoresis, and staphylococcal exotoxin gene testing. Results Of 1100 MRSA infections, 131 (12%) were community-associated and 937 (85%) were health care-associated; 32 (3%) could not be classified due to lack of information. Skin and soft tissue infections were more common among community-associated cases (75%) than among health care-associated cases (37%) (odds ratio [OR], 4.25; 95% confidence interval [CI], 2.97-5.90). Although community-associated MRSA isolates were more likely to be susceptible to 4 antimicrobial classes (adjusted OR,…

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  • Community-acquired MRSA isolates remain susceptible to multiple non-β-lactam antibiotics and possess distinct molecular features.

    “Isolates in these cases of community-acquired infection (CA-MRSA) remain susceptible to multiple non–β-lactam antibiotics and possess distinct molecular features (8).”

    From Postpartum Mastitis and Community-acquired Methicillin-resistant<i>Staphylococcus aureus</i> (2007) · cites this paper as [8]

  • Risk factors associated with skin and soft tissue infections due to community-acquired MRSA have been described.

    “Although risk factors associated with skin and soft tissue infections due to CA-MRSA have been described (8,9), characteristics unique to patients with CA-MRSA PPM are unknown.”

    From Postpartum Mastitis and Community-acquired Methicillin-resistant<i>Staphylococcus aureus</i> (2007) · cites this paper as [8]

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Authors
Naimi, T. S.
Affiliations
Minnesota Department of Health (US)
Corresponding author
Naimi, Timothy S.
ORCID
Naimi, Timothy S.
Venue
JAMA
Publisher
American Medical Association (AMA)
Published
2003-12-10
Volume
290
Issue
22
Pages
2976
ISSN
  • 0002-9955 (ISSN-L)
  • 0098-7484
DOI
10.1001/jama.290.22.2976
OpenAlex
W2135161828
Cited by
1,688
References
3
Citations by year
2026: 10 · 2025: 11 · 2024: 16 · 2023: 20 · 2022: 34 · 2021: 27 · 2020: 31 · 2019: 46 · 2018: 44 · 2017: 52 · 2016: 48 · 2015: 69 · 2014: 82 · 2013: 87 · 2012: 114
FWCI
59.40
Type
journal article
Language
en
Open access
closed
Locations
  • JAMA (publishedVersion)
  • PubMed (publishedVersion)
Funders
Centers for Disease Control and Prevention (U50/CCU511190)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
Keywords
methicillin-resistant Staphylococcus aureus, community-acquired MRSA, healthcare-associated MRSA, skin and soft tissue infections, antimicrobial susceptibility, Panton-Valentine leukocidin, MRSA epidemiology, antimicrobial resistance emergence, beta-lactam therapy
MeSH terms
Adult, Aged, Cross Infection, Humans, Microbial Sensitivity Tests, Middle Aged, Minnesota, Staphylococcal Infections, Staphylococcus aureus, Cohort Studies, Methicillin Resistance, Electrophoresis, Gel, Pulsed-Field, Community-Acquired Infections

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