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Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins
Abstract
Various heterotrimeric guanine nucleotide-binding proteins have been identified on the basis of the individual subtypes of their α subunits. The βγ complexes, composed of β and γ subunits, remain tightly associated under physiological conditions and have been assumed to constitute a common pool shared among various guanosine triphosphate (GTP)-binding (G) protein heterotrimers. Particular α and β subunit subtypes participate in the signal transduction processes between somatostatin or muscarinic receptors and the voltage-sensitive L-type calcium channel in rat pituitary GH 3 cells. Among γ subunits the γ 3 subtype was found to be required for coupling of the somatostatin receptor to voltage-sensitive calcium channels, whereas the γ 4 subtype was found to be required for coupling of the muscarinic receptor to those channels.
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Cited by
Koch, W. J., Hawes, B. E., Inglese, J., Luttrell, L. M., & Lefkowitz, R. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37587-7 · Cited by 421
Regulation of neural ion channels by muscarinic receptors
Brown, D. A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.11.024 · Cited by 44
Metadata
- Authors
- Kleuss, C., Scherübl, H., Hescheler, J., Schultz, G., & Wittig, B.
- Venue
- Science
- Published
- 1993-02-05
- Volume
- 259
- Issue
- 5096
- Pages
- 832-834
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1975614725
- Cited by
- 394
- References
- 0
- FWCI
- 18.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kleuss, C., Scherübl, H., Hescheler, J., Schultz, G., & Wittig, B. (1993). Selectivity in Signal Transduction Determined by γ Subunits of Heterotrimeric G Proteins. Science. https://doi.org/10.1126/science.8094261
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
