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NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
Abstract
The eukaryotic transcription factor nuclear factor-kappa B (NF-κB) participates in many parts of the genetic program mediating T lymphocyte activation and growth. Nuclear expression of NF-κB occurs after its induced dissociation from its cytoplasmic inhibitor IκBα. Phorbol ester and tumor necrosis factor-alpha induction of nuclear NF-κB is associated with both the degradation of performed IκBα and the activation of IκBα gene expression. Transfection studies indicate that the IκBα gene is specifically induced by the 65-kilodalton transactivating subunit of NF-κB. Association of the newly synthesized IκBα with p65 restores intracellular inhibition of NF-κB DNA binding activity and prolongs the survival of this labile inhibitor. Together, these results show that NF-κB controls the expression of IκBα by means of an inducible autoregulatory pathway.
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Cited by
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Activators and target genes of Rel/NF-κB transcription factors
Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727
Missing Pieces in the NF-κB Puzzle
Ghosh, S., & Karin, M. (2002) · Cell · doi:10.1016/s0092-8674(02)00703-1 · Cited by 3,638
Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390
NF-κB, Inflammation, and Metabolic Disease
Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952
Metadata
- Authors
- Sun, S.-C., Ganchi, P. A., Ballard, D. W., & Greene, W. C.
- Venue
- Science
- Published
- 1993-03-26
- Volume
- 259
- Issue
- 5103
- Pages
- 1912-1915
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051831012
- Cited by
- 1,104
- References
- 0
- FWCI
- 39.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sun, S.-C., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993). NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway. Science. https://doi.org/10.1126/science.8096091
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