The DOI matches its Crossref record.
Sequestration From Immune CD4 + T Cells of Mycobacteria Growing in Human Macrophages
Abstract
CD4 + helper T cells mediate resistance to tuberculosis, presumably by enhancing the antimicrobial activity of macrophages within which the Mycobacterium tuberculosis organism grows. A first step in resistance should be the presentation of mycobacterial antigens by macrophages to CD4 + T cells. However, when the antigenic stimulus is limited to organisms growing in human monocytes, the organisms become sequestered from immune CD4 + T cells. This block in presentation is selective for growing mycobacteria and not for other stimuli. Sequestration would allow replicating organisms to persist in infected individuals and may contribute to virulence.
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Cited by
Molloy, A., Laochumroonvorapong, P., & Kaplan, G. (1994) · The Journal of experimental medicine · doi:10.1084/jem.180.4.1499 · Cited by 508
Jagannath, C., Lindsey, D. R., Dhandayuthapani, S., Xu, Y., Hunter, R. L., & Eissa, N. T. (2009) · Nature Medicine · doi:10.1038/nm.1928 · Cited by 494
Regulation of antigen presentation by Mycobacterium tuberculosis: a role for Toll-like receptors
Harding, C. V., & Boom, W. H. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2321 · Cited by 435
Tuberculosis Vaccines and Prevention of Infection
Hawn, T. R., Day, T. A., Scriba, T. J., Hatherill, M., Hanekom, W. A., Evans, T. G., Churchyard, G. J., Kublin, J. G., Bekker, L.-G., & Self, S. G. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00021-14 · Cited by 164
CD4 + T Cells: Guardians of the Phagosome
Tubo, N. J., & Jenkins, M. K. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00097-13 · Cited by 105
Metadata
- Authors
- Pancholi, P., Mirza, A., Bhardwaj, N., & Steinman, R. M.
- Venue
- Science
- Published
- 1993-05-14
- Volume
- 260
- Issue
- 5110
- Pages
- 984-986
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2047460038
- Cited by
- 189
- References
- 0
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Sequestration From Immune CD4 + T Cells of Mycobacteria Growing in Human Macrophages. https://app.cochat.ai/papers/10.1126/science.8098550
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- Pancholi, P., Mirza, A., Bhardwaj, N., & Steinman, R. M. (1993). Sequestration From Immune CD4 + T Cells of Mycobacteria Growing in Human Macrophages. Science. https://doi.org/10.1126/science.8098550
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
