Tuberculosis Vaccines and Prevention of Infection

Hawn, Thomas R.; Day, Tracey A.; Scriba, Thomas J.; Hatherill, Mark; Hanekom, Willem A.; Evans, Thomas G.; Churchyard, Gavin J.; Kublin, James G.; Bekker, Linda-Gail; Self, Steven G.

doi:10.1128/mmbr.00021-14

Cited by 164Tuberculosis Research and EpidemiologyImmune responses and vaccinationsInfectious Diseases and Tuberculosis

Tuberculosis Vaccines and Prevention of Infection

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Hawn, Thomas R., Day, Tracey A., Scriba, Thomas J., Hatherill, Mark, Hanekom, Willem A., Evans, Thomas G., Churchyard, Gavin J., Kublin, James G. +2 more·2014·Microbiology and Molecular Biology Reviews

DOI 10.1128/mmbr.00021-14PMC PMC4248657

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Abstract

SUMMARY: Tuberculosis (TB) is a leading cause of death worldwide despite the availability of effective chemotherapy for over 60 years. Although Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccination protects against active TB disease in some populations, its efficacy is suboptimal. Development of an effective TB vaccine is a top global priority that has been hampered by an incomplete understanding of protective immunity to TB. Thus far, preventing TB disease, rather than infection, has been the primary target for vaccine development. Several areas of research highlight the importance of including preinfection vaccines in the development pipeline. First, epidemiology and mathematical modeling studies indicate that a preinfection vaccine would have a high population-level impact for control of TB disease. Second, immunology studies support the rationale for targeting prevention of infection, with evidence that host responses may be more effective during acute infection than during chronic infection. Third, natural history studies indicate that resistance to TB infection occurs in a small percentage of the population. Fourth, case-control studies of BCG indicate that it may provide protection from infection. Fifth, prevention-of-infection trials would have smaller sample sizes and a shorter duration than disease prevention trials and would enable opportunities to search for correlates of immunity as well as serve as a criterion for selecting a vaccine product for testing in a larger TB disease prevention trial. Together, these points support expanding the focus of TB vaccine development efforts to include prevention of infection as a primary goal along with vaccines or other interventions that reduce the rate of transmission and reactivation.

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BCG is the sole approved TB vaccine and offers only limited protection.
“Bacillus Calmette-Guerin (BCG), which was introduced in 1921, is the sole approved TB vaccine, but it offers only limited protection 132 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [132]

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Tuberculosis
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Prevention of M. tuberculosis Infection with H4:IC31 Vaccine or BCG Revaccination
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Nanotechnology approaches for global infectious diseases
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T cells and adaptive immunity to Mycobacterium tuberculosis in humans
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Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques
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Application of droplet digital PCR to detect the pathogens of infectious diseases
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Antibodies and tuberculosis
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The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial
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Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial
Ndiaye, B., Thienemann, F., Ota, M. O. C., Landry, B., Camara, M., Dièye, S., Dièye, T. N., Esmail, H., Goliath, R. T., Huygen, K., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00037-5 · Cited by 164 · see citing works
Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa
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Optimization and Interpretation of Serial QuantiFERON Testing to Measure Acquisition of Mycobacterium tuberculosis Infection
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Human Immunology of Tuberculosis
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Serial QuantiFERON testing and tuberculosis disease risk among young children: an observational cohort study
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Tuberculosis susceptibility and protection in children
Roy, R. B., Whittaker, E., Seddon, J. A., & Kampmann, B. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30157-9 · Cited by 139 · see citing works
Systematic review of mathematical models exploring the epidemiological impact of future TB vaccines
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Progress and challenges in TB vaccine development
Voss, G., Casimiro, D. R., Neyrolles, O., Williams, A., Kaufmann, S. H. E., McShane, H., Hatherill, M., & Fletcher, H. A. (2018) · F1000Research · doi:10.12688/f1000research.13588.1 · Cited by 114 · see citing works
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Tuberculosis Vaccine Development: Progress in Clinical Evaluation
Sable, S. B., Posey, J. E., & Scriba, T. J. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00100-19 · Cited by 113 · see citing works
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New Players in Immunity to Tuberculosis: The Host Microbiome, Lung Epithelium, and Innate Immune Cells
Gupta, N., Kumar, R. K., & Agrawal, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00709 · Cited by 87 · see citing works
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CD8+ T cell programming by cytomegalovirus vectors: applications in prophylactic and therapeutic vaccination
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Self-clearance of Mycobacterium tuberculosis infection: implications for lifetime risk and population at-risk of tuberculosis disease
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Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques
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Extrapulmonary Tuberculosis: Update on the Epidemiology, Risk Factors and Prevention Strategies
Ben, A. H., Makram, K., Marrakchi, C., Rekik, K., Hammami, F., Smaoui, F., Ben, H. M., Yaïch, S., Maâloul, I., Dammak, J., et al. (2018) · International Journal of Tropical Diseases · doi:10.23937/ijtd-2017/1710006 · Cited by 69 · see citing works
New Tuberculosis Vaccine Strategies: Taking Aim at Un-Natural Immunity
Jeyanathan, M., Yao, Y., Afkhami, S., Smaill, F., & Xing, Z. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.01.006 · Cited by 65 · see citing works
A comparison of effects of scalp nerve block and local anesthetic infiltration on inflammatory response, hemodynamic response, and postoperative pain in patients undergoing craniotomy for cerebral aneurysms: a randomized controlled trial
Yang, X., Ma, J., Li, K., Chen, L., Dong, R., Lu, Y., Zhang, Z., & Peng, M. (2019) · BMC Anesthesiology · doi:10.1186/s12871-019-0760-4 · Cited by 62 · see citing works
Dihydropyrimidinones Scaffold as a Promising Nucleus for Synthetic Profile and Various Therapeutic Targets: A Review
Khasimbi, S., Ali, F., Manda, K., Sharma, A., Chauhan, G., & Wakode, S. R. (2020) · Current Organic Synthesis · doi:10.2174/1570179417666201207215710 · Cited by 61 · see citing works
BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA– Indian adults
Rakshit, S., Ahmed, A., Adiga, V., Sundararaj, B. K., Sahoo, P. N., Kenneth, J., D′Souza, G., Bonam, W., Johnson, C., Franken, K. L. M. C., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.130540 · Cited by 60 · see citing works
A Randomized, Controlled Safety, and Immunogenicity Trial of the M72/AS01 Candidate Tuberculosis Vaccine in HIV-Positive Indian Adults
Kumarasamy, N., Poongulali, S., Bollaerts, A., Moris, P., Faith, B., Ayuk, L. N., Demoitié, M., Jongert, E., & Ofori‐Anyinam, O. (2016) · Medicine · doi:10.1097/md.0000000000002459 · Cited by 58 · see citing works
Effectiveness of BCG Vaccination Against Mycobacterium tuberculosis Infection in Adults: A Cross-sectional Analysis of a UK-Based Cohort
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Serum proteomics of active tuberculosis patients and contacts reveals unique processes activated during Mycobacterium tuberculosis infection
Mateos, J., Estévez, O., González‐Fernández, Á., Anibarro, L., Pallarés, Á., Reljić, R., Mussá, T., Gomes-Maueia, C., Nguilichane, A., Gallardo, J. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-60753-5 · Cited by 52 · see citing works
TIRAP, TRAM, and Toll-Like Receptors: The Untold Story
Lannoy, V., Côté-Biron, A., Asselin, C., & Rivard, N. (2023) · Mediators of Inflammation · doi:10.1155/2023/2899271 · Cited by 49 · see citing works
Research and development of new tuberculosis vaccines: a review
Schrager, L. K., Harris, R. C., & Vekemans, J. (2018) · F1000Research · doi:10.12688/f1000research.16521.1 · Cited by 49 · see citing works
Applications of bacteriophages against intracellular bacteria
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Identification and Analysis of Human Microbe-Disease Associations by Matrix Decomposition and Label Propagation
Qu, J., Zhao, Y. F., & Yin, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00291 · Cited by 46 · see citing works
Model Systems for Pulmonary Infectious Diseases: Paradigms of Anthrax and Tuberculosis
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Authors: Hawn, T. R., Day, T. A., Scriba, T. J., Hatherill, M., Hanekom, W. A., Evans, T. G., Churchyard, G. J., Kublin, J. G., Bekker, L.-G., & Self, S. G.
Affiliations: University of Washington (US)
Fred Hutch Cancer Center (US)
University of Cape Town (ZA)
Gates Foundation (US)
Aeras (US)
University of the Witwatersrand (ZA)
ORCID: Hawn, Thomas R.
Day, Tracey A.
Scriba, Thomas J.
Hatherill, Mark
Hanekom, Willem A.
Evans, Thomas G.
Churchyard, Gavin J.
Kublin, James G.
Bekker, Linda-Gail
Venue: Microbiology and Molecular Biology Reviews
Publisher: American Society for Microbiology
Published: 2014-12
Volume: 78
Issue: 4
Pages: 650-671
ISSN: 1092-2172 (ISSN-L)
1098-5557
DOI: 10.1128/mmbr.00021-14
PMC: PMC4248657
OpenAlex: W2137780892
Cited by: 164
References: 209
Citations by year: 2026: 3 · 2025: 8 · 2024: 8 · 2023: 8 · 2022: 16 · 2021: 14 · 2020: 15 · 2019: 21 · 2018: 22 · 2017: 23 · 2016: 20 · 2015: 6
FWCI: 2.27
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Microbiology and Molecular Biology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (84323)
National Institute of Allergy and Infectious Diseases (UM1AI068614, UM1AI068635)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords: tuberculosis vaccine development, BCG vaccine, protective immunity, natural resistance to infection, correlates of immunity, tuberculosis transmission, tuberculosis reactivation, tuberculosis epidemiology
MeSH terms: Animals, Clinical Trials as Topic, Humans, Models, Theoretical, Mycobacterium bovis, Mycobacterium tuberculosis, Tuberculosis, Vaccination, HIV Infections, Models, Animal, Tuberculosis Vaccines, Coinfection

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Tuberculosis Vaccines and Prevention of Infection

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