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Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands
Abstract
Most human peripheral blood γδ T lymphocytes respond to hitherto unidentified mycobacterial antigens. Four ligands from Mycobacterium tuberculosis strain H37Rv that stimulated proliferation of a major human γδ T cell subset were isolated and partially characterized. One of these ligands, TUBag4, is a 5′ triphosphorylated thymidine-containing compound, to which the three other stimulatory molecules are structurally related. These findings support the hypothesis that some γδ T cells recognize nonpeptidic ligands.
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Citations
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Metadata
- Authors
- Constant, P., Davodeau, F., Peyrat, M.-A., Poquet, Y., Puzo, G., Bonneville, M., & Fournié, J.-J.
- Venue
- Science
- Published
- 1994-04-08
- Volume
- 264
- Issue
- 5156
- Pages
- 267-270
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1972120590
- Cited by
- 711
- References
- 0
- FWCI
- 17.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Constant, P., Davodeau, F., Peyrat, M.-A., Poquet, Y., Puzo, G., Bonneville, M., & Fournié, J.-J. (1994). Stimulation of Human γδ T Cells by Nonpeptidic Mycobacterial Ligands. Science. https://doi.org/10.1126/science.8146660
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
