The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
Abstract
Transgenic mice were created with cardiac-specific overexpression of the β 2 -adrenergic receptor. This resulted in increased basal myocardial adenylyl cyclase activity, enhanced atrial contractility, and increased left ventricular function in vivo; these parameters at baseline in the transgenic animals were equal to those observed in control animals maximally stimulated with isoproterenol. These results illustrate a useful approach for studying the effect of gene expression on cardiac contractility. Because chronic heart failure in humans is accompanied by a reduction in the number of myocardial β-adrenergic receptors and in inotropic responsiveness, these results suggest a potential gene therapy approach to this disease state.
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Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cited by
Seven-transmembrane-spanning receptors and heart function
Rockman, H. A., Koch, W. J., & Lefkowitz, R. J. (2002) · Nature · doi:10.1038/415206a · Cited by 938
Self-citationAnimal Models of Heart Failure: A Scientific Statement From the American Heart Association
Houser, S. R., Margulies, K. B., Murphy, A. M., Spinale, F. G., Francis, G. S., Prabhu, S. D., Rockman, H. A., Kass, D. A., Molkentin, J. D., Sussman, M. A., et al. (2012) · Circulation Research · doi:10.1161/res.0b013e3182582523 · Cited by 435
Self-citationNikolaev, V. O., Bünemann, M., Schmitteckert, E., Lohse, M. J., & Engelhardt, S. (2006) · Circulation Research · doi:10.1161/01.res.0000250046.69918.d5 · Cited by 346
Catecholamines, Cardiac β-Adrenergic Receptors, and Heart Failure
Lefkowitz, R. J., Rockman, H. A., & Koch, W. J. (2000) · Circulation · doi:10.1161/01.cir.101.14.1634 · Cited by 291
Self-citationG protein-coupled receptor structure and function: the impact of disease-causing mutations
Shenker, A. (1995) · Baillière's Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(95)80519-2 · Cited by 81
Metadata
- Authors
- Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A., & Lefkowitz, R. J.
- Venue
- Science
- Published
- 1994-04-22
- Volume
- 264
- Issue
- 5158
- Pages
- 582-586
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2077425788
- Cited by
- 740
- References
- 1
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor. https://app.cochat.ai/papers/10.1126/science.8160017
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- Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A., & Lefkowitz, R. J. (1994). Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor. Science. https://doi.org/10.1126/science.8160017
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
