Catecholamines, Cardiac β-Adrenergic Receptors, and Heart Failure
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ADRs are widely expressed on virtually every cell type and play important roles in myocardial and vascular function and in regulation of body homeostasis in both health and pathologic states.
“ADRs are widely expressed on virtually every cell type, and known to play important roles in myocardial and vascular function, as well as regulation of body homeostasis in both health and pathologic states (Amrani and Bradding, 2017; Hein and Kobilka, 1997; Lefkowitz et al., 2000; Rockman et al., 2002).”
From A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors (2020) · cites this paper as Lefkowitz et al., 2000
Cites
The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial
Lechat, P. P., Brunhuber, K., Hofmann, R., Kuhn, P., Nesser, H., Slany, J., Weihs, W., Wiedermann, C. J., Wimmer, H., van Mieghem, W., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)11181-9 · Cited by 4,922 · see citing works
G PROTEIN–COUPLED RECEPTOR KINASES
Pitcher, J. A., Freedman, N. J., & Lefkowitz, R. J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.653 · Cited by 1,379 · see citing works
Self-citationSwitching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
Daaka, Y., Luttrell, L. M., & Lefkowitz, R. J. (1997) · Nature · doi:10.1038/36362 · Cited by 1,278 · see citing works
Self-citationProgressive hypertrophy and heart failure in β 1 -adrenergic receptor transgenic mice
Engelhardt, S. H., Hein, L., Wiesmann, F., & Lohse, M. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7059 · Cited by 784 · see citing works
Enhanced Myocardial Function in Transgenic Mice Overexpressing the β 2 -Adrenergic Receptor
Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A., & Lefkowitz, R. J. (1994) · Science · doi:10.1126/science.8160017 · Cited by 739 · see citing works
Self-citationCardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
Koch, W. J., Rockman, H. A., Samama, P., Hamilton, R., Bond, R. A., Milano, C. A., & Lefkowitz, R. J. (1995) · Science · doi:10.1126/science.7761854 · Cited by 719 · see citing works
Self-citationCommunal, C., Singh, K., Pimentel, D. R., & Colucci, W. S. (1998) · Circulation · doi:10.1161/01.cir.98.13.1329 · Cited by 690 · see citing works
Hall, R. A., Premont, R. T., Chow, C., Blitzer, J. T., Pitcher, J. A., Claing, A., Stoffel, R. H., Barak, L. S., Shenolikar, S., Weinman, E. J., et al. (1998) · Nature · doi:10.1038/33458 · Cited by 583 · see citing works
Self-citationCloning of the cDNA for the human beta 1-adrenergic receptor.
Frielle, T., Collins, S., Daniel, K. W., Caron, M. G., Lefkowitz, R. J., & Kobilka, B. K. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.22.7920 · Cited by 575 · see citing works
Self-citationFowler, M. B., Laser, J., Hopkins, G. L., et al. (1986) · Circulation · doi:10.1161/01.cir.74.6.1290 · Cited by 565 · see citing works
Rockman, H. A., Chien, K. R., Choi, D.-J., Iaccarino, G., Hunter, J. J., Ross, J., Lefkowitz, R. J., & Koch, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7000 · Cited by 488 · see citing works
Self-citationPROLONGATION OF SURVIVAL IN CONGESTIVE CARDIOMYOPATHY BY BETA-RECEPTOR BLOCKADE
Swedberg, K. B., Hjalmarson, Å. C., Waagstein, F., & Wallentin, I. (1979) · The Lancet · doi:10.1016/s0140-6736(79)92010-5 · Cited by 418 · see citing works
Early and Delayed Consequences of β 2 -Adrenergic Receptor Overexpression in Mouse Hearts
Liggett, S. B., Tepe, N. M., Lorenz, J. N., Canning, A. M., Jantz, T. D., Mitarai, S., Yatani, A., & Dorn, G. W. (2000) · Circulation · doi:10.1161/01.cir.101.14.1707 · Cited by 395 · see citing works
Coupling of β2-Adrenoceptor to GiProteins and Its Physiological Relevance in Murine Cardiac Myocytes
Xiao, R.-P., Avdonin, P. V., Zhou, Y.-Y., Cheng, H., Akhter, S. A., Thomas Eschenhagen, A., Lefkowitz, R. J., Koch, W. J., & Lakatta, E. G. (1999) · Circulation Research · doi:10.1161/01.res.84.1.43 · Cited by 389 · see citing works
Self-citationMacLellan, W. R., & Schneider, M. D. (1997) · Circulation Research · doi:10.1161/01.res.81.2.137 · Cited by 361 · see citing works
Adverse Effects of Chronic Endogenous Sympathetic Drive Induced by Cardiac G sα Overexpression
Iwase, M., Bishop, S. P., Uechi, M., et al. (1996) · Circulation Research · doi:10.1161/01.res.78.4.517 · Cited by 269 · see citing works
Iaccarino, G., Tomhave, E. D., Lefkowitz, R. J., et al. (1998) · Circulation · doi:10.1161/01.cir.98.17.1783 · Cited by 258 · see citing works
Self-citationDorn, G. W., Tepe, N. M., Lorenz, J. N., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.11.6400 · Cited by 231 · see citing works
Maurice, J. P., Hata, J. A., Shah, A. S., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6026 · Cited by 211 · see citing works
Xiao, R. P., Hohl, C. M., Altschuld, R. A., Jones, L. R., Livingston, B., Ziman, B. D., Tantini, B., & Lakatta, E. G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32287-1 · Cited by 200 · see citing works
Akhter, S. A., Skaer, C. A., Kypson, A. P., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12100 · Cited by 194 · see citing works
Turki, J., Lorenz, J. N., Green, S. A., Donnelly, E. T., Jacinto, M. T., & Liggett, S. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.19.10483 · Cited by 174 · see citing works
Rockman, H. A., Choi, D.-J., Akhter, S. A., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18180 · Cited by 166 · see citing works
Self-citationFunctional Consequences of Altering Myocardial Adrenergic Receptor Signaling
Koch, W. J., Lefkowitz, R. J., & Rockman, H. A. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.237 · Cited by 158 · see citing works
Self-citationTang, Y., Hu, L. A., Miller, W. E., Ringstad, N., Hall, R. A., Pitcher, J. A., Camilli, P. V. D., & Lefkowitz, R. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12559 · Cited by 148 · see citing works
Self-citationCho, M., Rapacciuolo, A., Koch, W. J., Kobayashi, Y. M., Jones, L. R., & Rockman, H. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.32.22251 · Cited by 121 · see citing works
Self-citationThe development of positive inotropic agents for chronic heart failure: How have we gone astray?
Packer, M. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90474-f · Cited by 112 · see citing works
Green, S. A., & Liggett, S. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47181-5 · Cited by 100 · see citing works
Akhter, S. A., Eckhart, A. D., Rockman, H. A., et al. (1999) · Circulation · doi:10.1161/01.cir.100.6.648 · Cited by 100 · see citing works
Self-citationKypson, A. P., Hendrickson, S. C., Akhter, S. A., et al. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300940 · Cited by 54 · see citing works
Transgenic Manipulation of Myocardial G Protein–Coupled Receptors and Receptor Kinases
Koch, W. J., Milano, C. A., & Lefkowitz, R. J. (1996) · Circulation Research · doi:10.1161/01.res.78.4.511 · Cited by 38 · see citing works
Self-citationNew Insight Into the Role of Enhanced Adrenergic Receptor-Effector Coupling in the Heart
Feldman, A. M., & McTiernan, C. F. (1999) · Circulation · doi:10.1161/01.cir.100.6.579 · Cited by 16 · see citing works
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A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors
Nemet, I., Saha, P. P., Gupta, N., Zhu, W., Romano, K. A., Skye, S. M., Cajka, T., Mohan, M. L., Li, L., Wu, Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.016 · Cited by 784 · see citing works
A mechanistic role for cardiac myocyte apoptosis in heart failure
Wencker, D., Chandra, M., Nguyen, K., Miao, W., Garantziotis, S., Factor, S. M., Shirani, J., Armstrong, R. C., & Kitsis, R. N. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17664 · Cited by 765 · see citing works
Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410 · see citing works
Adrenergic receptors and cardiovascular effects of catecholamines
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Oxygen‐sensing mechanisms in cells
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Ulla, A., Mohamed, M. K., Sikder, B., Rahman, A. T., Sumi, F. A., Hossain, M., Reza, H. M., Rahman, G. M. S., & Alam, M. A. (2017) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-017-0136-7 · Cited by 80 · see citing works
- Authors
- Lefkowitz, R. J., Rockman, H. A., & Koch, W. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Circulation
- Published
- 2000-04-11
- Volume
- 101
- Issue
- 14
- Pages
- 1634-1637
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2149649063
- Cited by
- 291
- References
- 32
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 11 · 2023: 7 · 2022: 6 · 2021: 13 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 13 · 2016: 15 · 2015: 10 · 2014: 5 · 2013: 11 · 2012: 12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- catecholamines, cardiac beta-adrenergic receptors, heart failure, beta-adrenergic blockade, sympathetic nervous system
- MeSH terms
- Animals, Cardiac Output, Low, Catecholamines, Humans, Myocardium, Receptors, Adrenergic, beta
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