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Chloramine Mutagenesis in Bacillus subtilis
Abstract
Chloramine (which occurs widely as a by-product of sanitary chlorination of water supplies) is shown to be a weak mutagen, when reversion of trp C to trp + in Bacillus subtilis is used as an assay. Some DNA-repair mutants appear to be more sensitive to chloramine, suggesting the involvement of DNA targets in bactericide. The influence of plating media on survival of cells treated with chloramine suggests a bacterial repair system acting upon potentially lethal lesions induced by chloramine.
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“The authors concluded that monochloramine is a weak mutagen in the trpC locus, when reversion of trpC to trp þ in B. subtilis is used as an assay (Shih and Lederberg 1976).”
From Inorganic chloramines: a critical review of the toxicological and epidemiological evidence as a basis for occupational exposure limit setting (2020) · cites this paper as Shih and Lederberg 1976
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Research works printed but not linked: 14
- ALPER, T, RESTORATION OF ESCHERICHIA-COLI STRAIN-B AFTER IRRADIATION - ITS DEPENDENCE ON SUBOPTIMAL GROWTH CONDITIONS, JOURNAL OF GENERAL MICROBIOLOGY 18: 461 (1958). · DOI
- ALPER, T, THE RELATIONSHIP BETWEEN GROWTH AND SURVIVAL AFTER IRRADIATION OF ESCHERICHIA-COLI STRAIN-B AND 2 RESISTANT MUTANTS, JOURNAL OF GENERAL MICROBIOLOGY 22: 113 (1960). · DOI
- BOYLE W.C. THESIS CALIFORNIA I (1963).
- CLARKE, C.H., CHEMICAL MUTAGENESIS IN E COLI B/R - INFLUENCE OF REPAIR SYSTEMS FOR UV DAMAGE, MUTATION RESEARCH 8: 35 (1969). · DOI
- HAYATSU, H, REACTION OF SODIUM HYPOCHLORITE WITH NUCLEIC ACIDS AND THEIR CONSTITUENTS, CHEMICAL & PHARMACEUTICAL BULLETIN 19: 2189 (1971). · DOI
- HILL, R.F., PHOTOCHEMISTRY AND PHOTOBIOLOGY 4: 563 (1965). · DOI
- ROSENKRANZ, H.S., SODIUM HYPOCHLORITE AND SODIUM PERBORATE - PREFERENTIAL INHIBITORS OF DNA POLYMERASE-DEFICIENT BACTERIA, MUTATION RESEARCH 21: 171 (1973). · DOI
- SHIH, K.L., EFFECTS OF CHLORAMINE ON BACILLUS-SUBTILIS DEOXYRIBONUCLEIC-ACID, JOURNAL OF BACTERIOLOGY 125: 934 (1976). · DOI
- SPIZIZEN, J, TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS-SUBTILIS BY DEOXYRIBONUCLEATE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 44: 1072 (1958).
- WITKIN, E.M., TIME, TEMPERATURE, AND PROTEIN SYNTHESIS - A STUDY OF ULTRAVIOLET-INDUCED MUTATION IN BACTERIA, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 21: 123 (1956). · DOI
- WITKIN, E.M., ULTRAVIOLET MUTAGENESIS IN POLA AND UVRA-POLA DERIVATIVES OF ESCHERICHIA-COLI B-R - EVIDENCE FOR AN INDUCIBLE ERROR-PRONE REPAIR SYSTEM, GENETICS 73: 91 (1973).
- WITKIN, E.M., ULTRAVIOLET MUTAGENESIS IN REPAIR-DEFICIENT DERIVATIVES OF ESCHERICHIA-COLI B/R - UVRA RECB AND UVRA RECC STRAINS, MUTATION RESEARCH 16: 235 (1972). · DOI
- WITKIN, E.M., REPAIR GENETIC RADIA: 151 (1962).
- WLODKOWSKI, T.J., MUTAGENICITY OF SODIUM-HYPOCHLORITE FOR SALMONELLA-TYPHIMURIUM, MUTATION RESEARCH 31: 39 (1975). · DOI
Cited by
Sorted by citations
Inorganic chloramines as drinking water disinfectants: a review
Wolfe, R. L., Ward, N. R., & Olson, B. H. (1984) · Journal AWWA · doi:10.1002/j.1551-8833.1984.tb05337.x · Cited by 162
Natural Antioxidant, Chlorogenic Acid, Protects Against DNA Breakage Caused by Monochloramine
SHIBATA, H., SAKAMOTO, Y., OKA, M., & KONO, Y. (1999) · Bioscience, Biotechnology, and Biochemistry · doi:10.1271/bbb.63.1295 · Cited by 91
Lahl, U., Bätjer, K., Düszeln, J. V., Gabel, B., Stachel, B., & Thiemann, W. (1981) · Water Research · doi:10.1016/0043-1354(81)90133-0 · Cited by 77
Wastensson, G., & Eriksson, K. (2020) · Critical Reviews in Toxicology · doi:10.1080/10408444.2020.1744514 · Cited by 30
Exon, J. H., Koller, L. D., O'Reilly, C. A., & Peter Bercz, J. (1987) · Toxicology · doi:10.1016/0300-483x(87)90028-x · Cited by 29
Metadata
- Authors
- Shih, K. L., & Lederberg, J.
- Affiliations
- Stanford Medicine (US)
- Venue
- Science
- Published
- 1976-06-11
- Volume
- 192
- Issue
- 4244
- Pages
- 1141-1143
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969083615
- Cited by
- 71
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2012: 3
- FWCI
- 1.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Profiles in Science (submittedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- chloramines, mutagenicity, Bacillus subtilis, DNA repair, bactericidal mechanism
- MeSH terms
- Bacillus subtilis, Chloramines, DNA Repair, Mutagens, Radiation Effects, Ultraviolet Rays, Water Supply
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