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Reversal of Terminal Differentiation Mediated by p107 in Rb -/- Muscle Cells
Abstract
The terminal differentiation of mammalian muscle cells requires the tumor suppressor retinoblastoma protein (Rb). Unlike their wild-type counterparts, multinucleated myotubes from mouse cells deficient in Rb (Rb -/- ) were induced by serum to reenter the cell cycle. Development of the myogenic phenotype in Rb -/- cells correlated with increased expression of p107, which interacted with myogenic transcription factors. Serum-induced cell cycle reentry, on the other hand, correlated with decreased p107 expression. Thus, although p107 could substitute for Rb as a cofactor for differentiation, it could not maintain the terminally differentiated state in Rb -/- myotubes.
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Cited by
Ellison, G. M., Vicinanza, C., Smith, A. J., Aquila, I., Leone, A., Waring, C. D., Henning, B. J., Stirparo, G. G., Papait, R., Scarfò, M., et al. (2013) · Cell · doi:10.1016/j.cell.2013.07.039 · Cited by 515
Self-citationHurford, R. K., Cobrinik, D., Lee, M. H., & Dyson, N. (1997) · Genes & Development · doi:10.1101/gad.11.11.1447 · Cited by 431
Yoshida, N., Yoshida, S., Koishi, K., Masuda, K., & Nabeshima, Y.-I. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.6.769 · Cited by 425
Guo, K., Wang, J., Andrés, V., Smith, R. C., & Walsh, K. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3823 · Cited by 423
Tsai, K. Y., Hu, Y., Macleod, K. F., Crowley, D., Yamasaki, L., & Jacks, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80274-9 · Cited by 372
Metadata
- Authors
- Schneider, J. W., Gu, W., Zhu, L., Mahdavi, V., & Nadal-Ginard, B.
- Venue
- Science
- Published
- 1994-06-03
- Volume
- 264
- Issue
- 5164
- Pages
- 1467-1471
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061645351
- Cited by
- 371
- References
- 0
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schneider, J. W., Gu, W., Zhu, L., Mahdavi, V., & Nadal-Ginard, B. (1994). Reversal of Terminal Differentiation Mediated by p107 in Rb -/- Muscle Cells. Science. https://doi.org/10.1126/science.8197461
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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