pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes

Hurford, R K; Cobrinik, D; Lee, M H; Dyson, N

doi:10.1101/gad.11.11.1447

Cited by 431Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsSignaling Pathways in Disease

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes

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Hurford, R K, Cobrinik, D, Lee, M H, Dyson, N·1997·Genes & Development

DOI 10.1101/gad.11.11.1447

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Abstract

The activity of the E2F transcription factor is controlled by physical association with the retinoblastoma protein (pRB) and two related proteins, p107 and p130. The pRB family members are thought to control different aspects of E2F activity, but it has been unclear what the respective functions of these proteins might be. To dissect the specific functions of pRB, p107, and p130 we have investigated how the expression of E2F-regulated genes is changed in cultures of primary cells lacking each of these family members. Whereas no changes were found in the expression of E2F-target genes in cells lacking either p107 or p130, deregulated expression of E2F targets was seen in cells lacking pRB and in cells lacking both p107 and p130. Surprisingly, the genes that were disregulated in these two settings were completely different. These findings show that pRB and p107/p130 indeed provide different functions in E2F regulation and identify target genes that are dependent on pRB family proteins for their normal expression.

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Previous studies suggested that RB family proteins regulate different E2F targets (Hurford et al., 1997) and that RB loss increases replication complex loading on chromatin (Srinivasan et al., 2007).
“Although previous studies hinted that RB family proteins can regulate different E2F targets (Hurford et al., 1997) and that loss of RB can ultimately lead to increased loading of replications complexes on chromatin (Srinivasan et al., 2007), the selectivity of RB towards repressing replication genes was not appreciated.”
From Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence (2010) · cites this paper as Hurford et al., 1997

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Sorted by citations

CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115 · see citing works
The regulation of E2F by pRB-family proteins.
Dyson, N. (1998) · Genes & Development · doi:10.1101/gad.12.15.2245 · Cited by 2,317 · see citing works
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Regulation of the G2/M transition by p53
Taylor, W. R., & Stark, G. R. (2001) · Oncogene · doi:10.1038/sj.onc.1204252 · Cited by 1,553 · see citing works
A Matter of Life and Cell Death
Evan, G. I., & Littlewood, T. D. (1998) · Science · doi:10.1126/science.281.5381.1317 · Cited by 1,515 · see citing works
Control of cell cycle transcription during G1 and S phases
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Retinoblastoma protein recruits histone deacetylase to repress transcription
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Sibling rivalry in the E2F family
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The Rb/E2F pathway: expanding roles and emerging paradigms
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E2F integrates cell cycle progression with DNA repair, replication, and G 2 /M checkpoints
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Rb Interacts with Histone Deacetylase to Repress Transcription
Luo, R. X., Postigo, A. A., & Dean, D. C. (1998) · Cell · doi:10.1016/s0092-8674(00)80940-x · Cited by 957 · see citing works
Rb targets histone H3 methylation and HP1 to promoters
Nielsen, S. J., Schneider, R., Bauer, U., Bannister, A. J., Morrison, A. J., O’Carroll, D., Firestein, R., Cleary, M. L., Jenuwein, T., Herrera, R. E., et al. (2001) · Nature · doi:10.1038/35087620 · Cited by 901 · see citing works
The retinoblastoma tumour suppressor in development and cancer
Classon, M., & Harlow, E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc950 · Cited by 738 · see citing works
The E2F transcriptional network: old acquaintances with new faces
Dimova, D. K., & Dyson, N. J. (2005) · Oncogene · doi:10.1038/sj.onc.1208612 · Cited by 715 · see citing works
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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells
Sutterlüty, H., Chatelain, E., Marti, A., Wirbelauer, C., Senften, M., Müller, U., & Krek, W. (1999) · Nature Cell Biology · doi:10.1038/12027 · Cited by 700 · see citing works
Pathogenesis of Human Papillomaviruses in Differentiating Epithelia
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NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcriptionPreprint
Zhao, J., Kennedy, B. K., Lawrence, B. D., Barbie, D. A., Matera, A. G., Fletcher, J. A., & Harlow, E. (2000) · Genes & Development · doi:10.1101/gad.827700 · Cited by 665 · see citing works
Human mesenchymal stem cells support megakaryocyte and pro-platelet formation from CD34+ hematopoietic progenitor cells
Cheng, L., Qasba, P., Vanguri, P., & Thiede, M. A. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200007)184:1 · Cited by 136 · see citing works
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression
Takahashi, Y., Rayman, J. B., & Dynlacht, B. D. (2000) · Genes & Development · doi:10.1101/gad.14.7.804 · Cited by 621 · see citing works
Pocket proteins and cell cycle control
Cobrinik, D. (2005) · Oncogene · doi:10.1038/sj.onc.1208619 · Cited by 601 · see citing works
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Targeted disruption of the three Rb-related genes leads to loss of G 1 control and immortalization
Sage, J., Mulligan, G. J., Attardi, L. D., Miller, A., Chen, S., Williams, B., Theodorou, E., & Jacks, T. (2000) · Genes & Development · doi:10.1101/gad.843200 · Cited by 582 · see citing works
The E2F family: specific functions and overlapping interests
Attwooll, C. L., Denchi, E. L., & Helin, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600481 · Cited by 568 · see citing works
Molecular mechanisms underlying RB protein function
Dick, F. A., & Rubin, S. M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3567 · Cited by 570 · see citing works
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry
Sage, J., Miller, A. L., Pérez-Mancera, P. A., Wysocki, J. M., & Jacks, T. (2003) · Nature · doi:10.1038/nature01764 · Cited by 538 · see citing works
The DREAM complex: master coordinator of cell cycle-dependent gene expression
Sadasivam, S., & DeCaprio, J. A. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3556 · Cited by 524 · see citing works
Assembly of cyclin D-dependent kinase and titration of p27 Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
Cheng, M., Sexl, V., Sherr, C. J., & Roussel, M. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.3.1091 · Cited by 496 · see citing works
Regulation of cell proliferation by the E2F transcription factors
Helin, K. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80058-0 · Cited by 491 · see citing works
The latent nuclear antigen of Kaposi sarcoma-associated herpesvirus targets the retinoblastoma–E2F pathway and with the oncogene Hras transforms primary rat cells
Radkov, S. A., Kellam, P., & Boshoff, C. (2000) · Nature Medicine · doi:10.1038/80459 · Cited by 489 · see citing works
RB1 : a prototype tumor suppressor and an enigmaPreprint
Dyson, N. J. (2016) · Genes & Development · doi:10.1101/gad.282145.116 · Cited by 437 · see citing works
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Cell-cycle inhibitors: three families united by a common cause
Vidal, A., & Koff, A. (2000) · Gene · doi:10.1016/s0378-1119(00)00092-5 · Cited by 429 · see citing works
Ablation of the Retinoblastoma gene family deregulates G1 control causing immortalization and increased cell turnover under growth-restricting conditions
Dannenberg, J.-H., van Rossum, A., Schuijff, L., & te Riele, H. (2000) · Genes & Development · doi:10.1101/gad.847700 · Cited by 413 · see citing works
The retinoblastoma gene family in differentiation and development
Lipinski, M. M., & Jacks, T. (1999) · Oncogene · doi:10.1038/sj.onc.1203244 · Cited by 404 · see citing works
PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 familyPreprint
Attardi, L. D., Reczek, E. E., Cosmas, C., Demicco, E. G., McCurrach, M. E., Lowe, S. W., & Jacks, T. (2000) · Genes & Development · doi:10.1101/gad.14.6.704 · Cited by 394 · see citing works
Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities
Stead, E., White, J., Faast, R., Conn, S. J., Goldstone, S. D., Rathjen, J., Dhingra, U., Rathjen, P. D., Walker, D., & Dalton, S. (2002) · Oncogene · doi:10.1038/sj.onc.1206015 · Cited by 389 · see citing works
Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
Chicas, A., Wang, X., Zhang, C., McCurrach, M., Zhao, Z., Mert, O., Dickins, R. A., Narita, M., Zhang, M., & Lowe, S. W. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.023 · Cited by 388 · see citing works
Control of pRB phosphorylation
Mittnacht, S. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80057-9 · Cited by 385 · see citing works
Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumorsPreprint
McClatchey, A. I., Saotome, I., Mercer, K. L., Crowley, D. G., Gusella, J. F., Bronson, R. T., & Jacks, T. (1998) · Genes & Development · doi:10.1101/gad.12.8.1121 · Cited by 388 · see citing works
Myc and the cell cycle
Amati, B. B. (1998) · Frontiers in bioscience · doi:10.2741/a239 · Cited by 367 · see citing works
The Retinoblastoma Protein Acts as a Transcriptional Coactivator Required for Osteogenic Differentiation
Thomas, D. M., Carty, S. A., Piscopo, D. M., Lee, J.-S., Wang, W.-F., Forrester, W. C., & Hinds, P. W. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00327-6 · Cited by 361 · see citing works
Retinoblastoma protein partners
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Emerging roles for E2F: Beyond the G1/S transition and DNA replication
Cam, H. P., & Dynlacht, B. D. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00080-1 · Cited by 344 · see citing works
E2f3 is critical for normal cellular proliferationPreprint
Humbert, P. O., Verona, R. I., Trimarchi, J. M., Rogers, C., Dandapani, S. V., & Lees, J. A. (2000) · Genes & Development · doi:10.1101/gad.14.6.690 · Cited by 334 · see citing works
The retinoblastoma gene family: cousins with overlapping interests
Mulligan, G. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(98)01470-x · Cited by 334 · see citing works
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase
Vigo, E., Müller, H., Prosperini, E., Hateboer, G., Cartwright, P., Moroni, M. C., & Helin, K. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.9.6379 · Cited by 326 · see citing works
A Common Set of Gene Regulatory Networks Links Metabolism and Growth Inhibition
Cam, H., Balciunaite, E., Blais, A., Spektor, A., Scarpulla, R. C., Young, R., Kluger, Y., & Dynlacht, B. D. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.09.037 · Cited by 322 · see citing works
Cyclin C/Cdk3 Promotes Rb-Dependent G0 Exit
Ren, S., & Rollins, B. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00300-9 · Cited by 316 · see citing works
E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control
Gaubatz, S., Lindeman, G. J., Ishida, S., Jakoi, L., Nevins, J. R., Livingston, D. M., & Rempel, R. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00071-x · Cited by 300 · see citing works
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
Morris, E. J., Ji, J., Yang, F., Stefano, L. D., Herr, A., Moon, N. S., Kwon, E. J., Haigis, K. M., Näär, A. M., & Dyson, N. J. (2008) · Nature · doi:10.1038/nature07310 · Cited by 297 · see citing works
Self-citation
The genetics of the E2F family of transcription factors: shared functions and unique roles
DeGregori, J. V. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00051-3 · Cited by 295 · see citing works
E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
Rayman, J. B., Takahashi, Y., Indjeian, V. B., Dannenberg, J.-H., Catchpole, S., Watson, R. J., te Riele, H., & Dynlacht, B. D. (2002) · Genes & Development · doi:10.1101/gad.969202 · Cited by 288 · see citing works
The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division cycle
Henley, S. A., & Dick, F. A. (2012) · Cell Division · doi:10.1186/1747-1028-7-10 · Cited by 279 · see citing works
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation
Johnson, B. R., Nitta, R. T., Frock, R. L., Mounkes, L. C., Barbie, D. A., Stewart, C. L., Harlow, E., & Kennedy, B. K. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403250101 · Cited by 282 · see citing works
The E2F transcription factors: key regulators of cell proliferation
Müller, H., & Helin, K. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(99)00030-x · Cited by 259 · see citing works
Cell cycle transcription control: DREAM/MuvB and RB-E2F complexes.
Fischer, M., & Müller, G. A. (2017) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2017.1360836 · Cited by 255 · see citing works
Biology of human papillomaviruses
McMurray, H. R., Nguyen, D. X., Westbrook, T. F., & McCance, D. J. (2001) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.2001.00177.x · Cited by 253 · see citing works
Control of cell proliferation by Myc
Bouchard, C., Staller, P., & Eilers, M. (1998) · Trends in Cell Biology · doi:10.1016/s0962-8924(98)01251-3 · Cited by 253 · see citing works
Cell cycle regulation and neural differentiation
Galderisi, U., Jori, F. P., & Giordano, A. (2003) · Oncogene · doi:10.1038/sj.onc.1206558 · Cited by 248 · see citing works
Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
Zhao, Y., Tan, J. Y., Zhuang, L., Jiang, X., Liu, E. T., & Yu, Q. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505585102 · Cited by 246 · see citing works
pRB plays an essential role in cell cycle arrest induced by DNA damage
Harrington, E. A., Bruce, J. L., Harlow, E., & Dyson, N. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11945 · Cited by 242 · see citing works
Self-citation
Mechanisms of action of flavopiridol
Sedlacek, H. H. (2001) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(00)00124-4 · Cited by 240 · see citing works
Cell cycle-dependent and cell cycle-independent control of transcription by theDrosophilaE2F/RB pathwayPreprint
Dimova, D. K., Nolan-Stevaux, O., Frolov, M. V., & Dyson, N. J. (2003) · Genes & Development · doi:10.1101/gad.1116703 · Cited by 235 · see citing works
Self-citation
p107 and p130: Versatile Proteins with Interesting Pockets
Classon, M., & Dyson, N. J. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5135 · Cited by 237 · see citing works
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Target gene specificity of E2F and pocket protein family members in living cells
Wells, J., Boyd, K. E., Fry, C. J., Bartley, S. M., & Farnham, P. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.5797-5807.2000 · Cited by 229 · see citing works
Cell type-specific effects of Rb deletion in the murine retina
MacPherson, D., Sage, J., Kim, T., Ho, D., McLaughlin, M. E., & Jacks, T. (2004) · Genes & Development · doi:10.1101/gad.1203304 · Cited by 222 · see citing works
Cyclin-Dependent Kinases
Harper, J. W., & Adams, P. D. (2001) · Chemical Reviews · doi:10.1021/cr0001030 · Cited by 220 · see citing works
Myb proteins in life, death and differentiation
Weston, K. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80065-8 · Cited by 213 · see citing works
Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progressionPreprint
Knudsen, E. S., Buckmaster, C., Chen, T.-T., Feramisco, J. R., & Wang, J. Y. J. (1998) · Genes & Development · doi:10.1101/gad.12.15.2278 · Cited by 210 · see citing works
Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
de Vries, A., Flores, E. R., Miranda, B., Hsieh, H.-M., van Oostrom, C. T. M., Sage, J., & Jacks, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052713099 · Cited by 207 · see citing works
E2F and cell cycle control: a double-edged sword
Stevens, C., & Thangue, N. B. L. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(03)00054-7 · Cited by 203 · see citing works
E2F4 Is Essential for Normal Erythrocyte Maturation and Neonatal Viability
Humbert, P. O., Rogers, C., Ganiatsas, S., Landsberg, R. L., Trimarchi, J. M., Dandapani, S. V., Brugnara, C., Erdman, S. E., Schrenzel, M. D., Bronson, R. T., et al. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00029-0 · Cited by 193 · see citing works
Regulation of G1 cell-cycle progression by oncogenes and tumor suppressor genes
Ho, A. L. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(01)00263-5 · Cited by 192 · see citing works
Identification of a Novel E2F3 Product Suggests a Mechanism for Determining Specificity of Repression by Rb Proteins
Leone, G. W., Nuckolls, F., Ishida, S., Adams, M., Sears, R. C., Jakoi, L., Miron, A., & Nevins, J. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.10.3626-3632.2000 · Cited by 187 · see citing works
Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes
Adams, P. D., Li, X., Sellers, W. R., Baker, K., Leng, X., Harper, J. W., Taya, Y., & Kaelin, W. G. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1068 · Cited by 185 · see citing works
Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
LeCouter, J. E., Kablar, B., Whyte, P., Ying, C., & Rudnicki, M. A. (1998) · Development · doi:10.1242/dev.125.23.4669 · Cited by 181 · see citing works
Cell Cycle-Regulated Expression of Mammalian CDC6 Is Dependent on E2F
Hateboer, G., Wobst, A. H. K., Petersen, B. O., Cam, L. L., Vigo, E., Sardet, C., & Helin, K. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6679 · Cited by 180 · see citing works
Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6
Gaubatz, S., Wood, J. G., & Livingston, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9190 · Cited by 180 · see citing works
Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks
Adams, P. D. (2001) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(01)00019-1 · Cited by 177 · see citing works
Cell Death in Chondrocytes, Osteoblasts, and Osteocytes
Komori, T. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122045 · Cited by 176 · see citing works
Regulation of DNA Methyltransferase 1 by the pRb/E2F1 Pathway
McCabe, M. T., Davis, J. N., & Day, M. L. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-2158 · Cited by 172 · see citing works
Oxidative DNA damage, antioxidants, and cancer
Collins, A. R. (1999) · BioEssays · doi:10.1002/(sici)1521-1878(199903)21:3 · Cited by 312 · see citing works
Gene Expression and Cell Cycle Arrest Mediated by Transcription Factor DMP1 Is Antagonized by D-Type Cyclins through a Cyclin-Dependent-Kinase-Independent Mechanism
Inoue, K., & Sherr, C. J. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1590 · Cited by 168 · see citing works
The retinoblastoma tumor-suppressor gene, the exception that proves the rule
Goodrich, D. W. (2006) · Oncogene · doi:10.1038/sj.onc.1209616 · Cited by 166 · see citing works
Requirement for p27KIP1 in Retinoblastoma Protein-Mediated Senescence
Alexander, K., & Hinds, P. W. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.11.3616-3631.2001 · Cited by 164 · see citing works
Cell Type-Specific Role of the Retinoblastoma/E2F Pathway during Arabidopsis Leaf Development
Desvoyes, B., Ramírez-Parra, E., Xie, Q., Chua, N., & Gutiérrez, C. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.071027 · Cited by 164 · see citing works
Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53
Pierce, A. M., Gimenez-Conti, I. B., Schneider‐Broussard, R., Martinez, L. A., Conti, C. J., & Johnson, D. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.15.8858 · Cited by 156 · see citing works
The J Domain of Simian Virus 40 Large T Antigen Is Required To Functionally Inactivate RB Family Proteins
Zalvide, J. B., Stubdal, H., & DeCaprio, J. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1408 · Cited by 150 · see citing works
Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins
Felsani, A., Mileo, A. M., & Paggi, M. G. (2006) · Oncogene · doi:10.1038/sj.onc.1209621 · Cited by 149 · see citing works
Retinoblastoma protein meets chromatin
Brehm, A., & Kouzarides, T. (1999) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(99)01368-7 · Cited by 148 · see citing works
Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis
Ruiz, S., Santos, M., Segrelles, C., Leis, H., Jorcano, J. L., Berns, A., Paramio, J. M., & Vooijs, M. (2004) · Development · doi:10.1242/dev.01148 · Cited by 147 · see citing works
Requirements for Cell Cycle Arrest by p16INK4a
Bruce, J. L., Hurford, R. K., Classon, M., Koh, J., & Dyson, N. J. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00072-1 · Cited by 146 · see citing works
Self-citation
Bcl-2 Retards Cell Cycle Entry through p27Kip1, pRB Relative p130, and Altered E2F Regulation
Vairo, G., Soos, T. J., Upton, T. M., Zalvide, J. B., DeCaprio, J. A., Ewen, M. E., Koff, A., & Adams, J. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4745-4753.2000 · Cited by 144 · see citing works
Contribution of p16 INK4a and p21 CIP1 pathways to induction of premature senescence of human endothelial cells: permissive role of p53
Chen, J., Huang, X., Halicka, D., Brodsky, S., Avram, A., Eskander, J., Bloomgarden, N. A., Darzynkiewicz, Z., & Goligorsky, M. S. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00364.2005 · Cited by 142 · see citing works
pRB Contains an E2F1-Specific Binding Domain that Allows E2F1-Induced Apoptosis to Be Regulated Separately from Other E2F Activities
Dick, F. A., & Dyson, N. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00344-7 · Cited by 142 · see citing works
Self-citation
Strain-Dependent Myeloid Hyperplasia, Growth Deficiency, and Accelerated Cell Cycle in Mice Lacking the Rb-Related p107 Gene
LeCouter, J. E., Kablar, B., Hardy, W. R., Ying, C., Megeney, L. A., May, L. L., & Rudnicki, M. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.12.7455 · Cited by 141 · see citing works
Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130
Dannenberg, J.-H., Schuijff, L., Dekker, M., van der Valk, M., & Riele, H. T. (2004) · Genes & Development · doi:10.1101/gad.322004 · Cited by 137 · see citing works
Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer
DiCiommo, D. P., Gallie, B. L., & Bremner, R. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0326 · Cited by 137 · see citing works
RETRACTED: Elevated tRNAiMet Synthesis Can Drive Cell Proliferation and Oncogenic Transformation
Marshall, L., Kenneth, N. S., & White, R. J. (2008) · Cell · doi:10.1016/j.cell.2008.02.035 · Cited by 132 · see citing works
Retracted
E2F and Histone Deacetylase Mediate Transforming Growth Factor β Repression of cdc25A during Keratinocyte Cell Cycle Arrest
Iavarone, A., & Massagué, J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.916 · Cited by 132 · see citing works
The Retinoblastoma Protein Regulates Pericentric Heterochromatin
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Authors: Hurford, R. K., Cobrinik, D., Lee, M. H., & Dyson, N.
Affiliations: Massachusetts General Hospital (US)
ORCID: Cobrinik, D
Dyson, N
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 1997-06-01
Volume: 11
Issue: 11
Pages: 1447-1463
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.11.11.1447
OpenAlex: W2151812144
Cited by: 431
References: 85
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 5 · 2013: 11 · 2012: 7
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA64402, R01CA064402)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: retinoblastoma protein, p107, p130, E2F transcription factors, E2F target genes, gene expression regulation, cell cycle regulation, cell cycle-dependent transcription
MeSH terms: Animals, Carrier Proteins, Cell Cycle, Cells, Cultured, DNA-Binding Proteins, Embryo, Mammalian, Fibroblasts, Gene Expression Regulation, Nuclear Proteins, Phosphoproteins, Promoter Regions, Genetic, Protein Binding, Proteins, Transcription Factors, Transfection, Trans-Activators, Retinoblastoma Protein, Culture Media, Serum-Free, Genes, Reporter, Mice, Knockout, Cell Cycle Proteins, Transcription Factor DP1, E2F Transcription Factors, Retinoblastoma-Like Protein p130, Retinoblastoma-Like Protein p107, Mice, Retinoblastoma-Binding Protein 1

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pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes

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