The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Structural Basis of Sequence-Independent Peptide Binding by OppA Protein
Abstract
Specific protein-ligand interactions are critical for cellular function, and most proteins select their partners with sharp discrimination. However, the oligopeptide-binding protein of Salmonella typhimurium (OppA) binds peptides of two to five amino acid residues without regard to sequence. The crystal structure of OppA reveals a three-domain organization, unlike other periplasmic binding proteins. In OppA-peptide complexes, the ligands are completely enclosed in the protein interior, a mode of binding that normally imposes tight specificity. The protein fulfills the hydrogen bonding and electrostatic potential of the ligand main chain and accommodates the peptide side chains in voluminous hydrated cavities.
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Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
Research works printed but not linked: 26
- ABOUHAMAD, W.N., PEPTIDE-TRANSPORT AND CHEMOTAXIS IN ESCHERICHIA-COLI AND SALMONELLA-TYPHIMURIUM - CHARACTERIZATION OF THE DIPEPTIDE PERMEASE (DPP) AND THE DIPEPTIDE-BINDING PROTEIN, MOLECULAR MICROBIOLOGY 5: 1035 (1991). · DOI
- AMES, B.N., ILLICIT TRANSPORT - OLIGOPEPTIDE PERMEASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 70: 456 (1973).
- AMES, GFL, BACTERIAL PERIPLASMIC TRANSPORT-SYSTEMS - STRUCTURE, MECHANISM, AND EVOLUTION, ANNUAL REVIEW OF BIOCHEMISTRY 55: 397 (1986). · DOI · Paper page
- COWTAN, K. D., ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 49: 148 (1993).
- FICKEL, T. E., NATURE-NEW BIOLOGY 241: 161 (1973).
- GOODELL, E.W., UPTAKE OF CELL-WALL PEPTIDES BY SALMONELLA-TYPHIMURIUM AND ESCHERICHIA-COLI, JOURNAL OF BACTERIOLOGY 169: 3861 (1987). · DOI · Paper page
- GUYER, C.A., BINDING-SPECIFICITY OF THE PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN FROM ESCHERICHIA-COLI, JOURNAL OF BACTERIOLOGY 168: 775 (1986). · DOI
- HAMMOND, S.M., A NEW CLASS OF SYNTHETIC ANTIBACTERIALS ACTING ON LIPOPOLYSACCHARIDE BIOSYNTHESIS, NATURE 327: 730 (1987). · DOI
- HANSON, M.S., THE HBPA GENE OF HAEMOPHILUS-INFLUENZAE TYPE-B ENCODES A HEME-BINDING LIPOPROTEIN CONSERVED AMONG HEME-DEPENDENT HAEMOPHILUS SPECIES, INFECTION AND IMMUNITY 60: 2257 (1992). · DOI
- 10.1126/science.1925561 · DOI · Paper page
- HIGGINS, C, MICROBIOLOGY - SYNTHESIZING DESIGNER DRUGS, NATURE 327: 655 (1987). · doi:10.1038/327655a0
- HIGGINS, C.F., ABC TRANSPORTERS - FROM MICROORGANISMS TO MAN, ANNUAL REVIEW OF CELL BIOLOGY 8: 67 (1992). · DOI · Paper page
- HILES, I.D., PEPTIDE UPTAKE BY SALMONELLA-TYPHIMURIUM - THE PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN, EUROPEAN JOURNAL OF BIOCHEMISTRY 158: 561 (1986). · doi:10.1111/j.1432-1033.1986.tb09791.x
- 10.1107/S0021889891004399 · DOI · Paper page
- 10.1126/science.7901913 · DOI
- MADDEN, D.R., THE STRUCTURE OF HLA-B27 REVEALS NONAMER SELF-PEPTIDES BOUND IN AN EXTENDED CONFORMATION, NATURE 353: 321 (1991). · DOI · Paper page
- MOWBRAY, S.L., 1-BULLET-7 ANGSTROM X-RAY STRUCTURE OF THE PERIPLASMIC RIBOSE RECEPTOR FROM ESCHERICHIA-COLI, JOURNAL OF MOLECULAR BIOLOGY 225: 155 (1992). · DOI
- NAVARRO, C, THE NIK OPERON OF ESCHERICHIA-COLI ENCODES A PERIPLASMIC BINDING-PROTEIN-DEPENDENT TRANSPORT-SYSTEM FOR NICKEL, MOLECULAR MICROBIOLOGY 9: 1181 (1993). · DOI · Paper page
- OH, B.H., 3-DIMENSIONAL STRUCTURES OF THE PERIPLASMIC LYSINE ARGININE ORNITHINE-BINDING PROTEIN WITH AND WITHOUT A LIGAND, JOURNAL OF BIOLOGICAL CHEMISTRY 268: 11348 (1993). · DOI · Paper page
- OLSON, E.R., IDENTIFICATION AND CHARACTERIZATION OF DPPA, AN ESCHERICHIA-COLI GENE ENCODING A PERIPLASMIC DIPEPTIDE TRANSPORT PROTEIN, JOURNAL OF BACTERIOLOGY 173: 234 (1991). · DOI
- Payne, J. W., Journal of Biological Chemistry 243: 6291 (1968). · doi:10.1016/s0021-9258(18)94490-x
- PAYNE, J.W., PEPTIDE TRANSPORT, ADVANCES IN ENZYMOLOGY AND RELATED AREAS OF MOLECULAR BIOLOGY 35: 187 (1971).
- QUIOCHO, F.A., CURR OPIN STRUC BIOL 1: 922 (1991). · doi:10.1016/0959-440x(91)90087-a
- 10.1107/S0108767386099622 · DOI · Paper page
- TAN, R, MICROBIOL REV 57: 320 (1993). · doi:10.1128/mr.57.2.320-346.1993 · Paper page
- TOLLEY, S.P., CRYSTALLIZATION OF THE PERIPLASMIC OLIGOPEPTIDE-BINDING PROTEIN OF SALMONELLA-TYPHIMURIUM, JOURNAL OF MOLECULAR BIOLOGY 204: 493 (1988). · doi:10.1016/0022-2836(88)90591-8
Cited by
ABC transporters: physiology, structure and mechanism – an overview
Higgins, C. F. (2001) · Research in Microbiology · doi:10.1016/s0923-2508(01)01193-7 · Cited by 641
Self-citation[28] Phase determination from multiwavelength anomalous diffraction measurements
Hendrickson, W. A., & Ogata, C. M. (1997) · Methods in Enzymology · doi:10.1016/s0076-6879(97)76074-9 · Cited by 349
Garmory, H. S., & Titball, R. W. (2004) · Infection and Immunity · doi:10.1128/iai.72.12.6757-6763.2004 · Cited by 293
Doeven, M. K., Kok, J., & Poolman, B. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04698.x · Cited by 100
Reconstruction of the proteolytic pathway for use of β‐casein by Lactococcus lactis
Kunji, E. R. S., Fang, G., Jeronimus‐Stratingh, C. M., Bruins, A. P., Poolman, B., & Konings, W. N. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00769.x · Cited by 66
Metadata
- Authors
- Tame, J. R. H., Murshudov, G. N., Dodson, E. J., Neil, T. K., Dodson, G. G., Higgins, C. F., & Wilkinson, A. J.
- Venue
- Science
- Published
- 1994-06-10
- Volume
- 264
- Issue
- 5165
- Pages
- 1578-1581
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2141906439
- Cited by
- 233
- References
- 1
- FWCI
- 13.43
- Type
- journal article
- Language
- en
- Open access
- closed
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