The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells
Abstract
Although many T cells carry two in-frame V α rearrangements, the products of both V α rearrangements have never been shown simultaneously on the surface of normal cells. With the use of monoclonal antibodies to V α 2, V α 12, and V α 24, up to one-third of mature T cells expressed two V α chains as part of two functional and independent T cell receptors (TCRs). Thus, the "one cell, one receptor" rule does not apply to a large subset of αβ T cells. Cells that belong to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor, which may be important for autoimmunity and alloreactivity.
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Cites
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Cited by
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A Direct Estimate of the Human αβ T Cell Receptor Diversity
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Metadata
- Authors
- Padovan, E., Casorati, G., Dellabona, P., Meyer, S., Brockhaus, M., & Lanzavecchia, A.
- Venue
- Science
- Published
- 1993-10-15
- Volume
- 262
- Issue
- 5132
- Pages
- 422-424
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2019638830
- Cited by
- 549
- References
- 9
- FWCI
- 15.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Padovan, E., Casorati, G., Dellabona, P., Meyer, S., Brockhaus, M., & Lanzavecchia, A. (1993). Expression of Two T Cell Receptor α Chains: Dual Receptor T Cells. Science. https://doi.org/10.1126/science.8211163
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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