The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
A Yeast Protein Similar to Bacterial Two-Component Regulators
Abstract
Many bacterial signaling pathways involve a two-component design. In these pathways, a sensor kinase, when activated by a signal, phosphorylates its own histidine, which then serves as a phosphoryl donor to an aspartate in a response regulator protein. The Sln1 protein of the yeast Saccharomyces cerevisiae has sequence similarities to both the histidine kinase and the response regulator proteins of bacteria. A missense mutation in SLN1 is lethal in the absence but not in the presence of the N-end rule pathway, a ubiquitin-dependent proteolytic system. The finding of SLN1 demonstrates that a mode of signal transduction similar to the bacterial two-component design operates in eukaryotes as well.
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Cites
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In Vivo Half-Life of a Protein Is a Function of Its Amino-Terminal Residue
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Self-citationArabidopsis Ethylene-Response Gene ETR1 : Similarity of Product to Two-Component Regulators
Chang, C., Kwok, S. F., Bleecker, A. B., & Meyerowitz, E. M. (1993) · Science · doi:10.1126/science.8211181 · Cited by 1,521
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COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS
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[19] Targeting, disruption, replacement, and allele rescue: Integrative DNA transformation in yeast
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Self-citation
Cited by
Osmotic Stress Signaling and Osmoadaptation in Yeasts
Hohmann, S. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.300-372.2002 · Cited by 1,767
Signal Transduction through MAP Kinase Cascades
(1998) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
Ethylene-inducible DNA binding proteins that interact with an ethylene-responsive element.
Ohme-Takagi, M., & Shinshi, H. (1995) · The Plant Cell · doi:10.1105/tpc.7.2.173 · Cited by 1,243
Cell Wall Integrity Signaling in Saccharomyces cerevisiae
Levin, D. E. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.262-291.2005 · Cited by 1,136
A two-component system that regulates an osmosensing MAP kinase cascade in yeast
Maeda, T., Wurgler-Murphy, S. M., & Saito, H. (1994) · Nature · doi:10.1038/369242a0 · Cited by 1,076
Metadata
- Authors
- Ota, I. M., & Varshavsky, A.
- Venue
- Science
- Published
- 1993-10-22
- Volume
- 262
- Issue
- 5133
- Pages
- 566-569
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1982051667
- Cited by
- 428
- References
- 31
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
