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The Influence of Antigen Organization on B Cell Responsiveness
Abstract
The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form in the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance.
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Citations
Cited by
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
Bachmann, M. F., & Jennings, G. T. (2010) · Nature Reviews Immunology · doi:10.1038/nri2868 · Cited by 2,106
Self-citationMajor findings and recent advances in virus–like particle (VLP)-based vaccines
Mohsen, M. O., Zha, L., Cabral-Miranda, G., & Bachmann, M. F. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.08.014 · Cited by 555
Self-citationRole of nanoscale antigen organization on B-cell activation probed using DNA origami
Veneziano, R., Moyer, T. J., Stone, M. B., Wamhoff, E.-C., Read, B. J., Mukherjee, S., Shepherd, T. R., Das, J., Schief, W. R., Irvine, D. J., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0719-0 · Cited by 429
Bioengineering virus‐like particles as vaccines
Lua, L. H. L., Connors, N. K., Sainsbury, F., Chuan, Y. P., Wibowo, N., & Middelberg, A. P. J. (2014) · Biotechnology and Bioengineering · doi:10.1002/bit.25159 · Cited by 355
Impact of Product-Related Factors on Immunogenicity of Biotherapeutics
Singh, S. K. (2011) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.22276 · Cited by 350
Metadata
- Authors
- Bachmann, M. F., Rohrer, U. H., Kündig, T. M., Bürki, K., Hengartner, H., & Zinkernagel, R. M.
- Venue
- Science
- Published
- 1993-11-26
- Volume
- 262
- Issue
- 5138
- Pages
- 1448-1451
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055861239
- Cited by
- 717
- References
- 0
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Influence of Antigen Organization on B Cell Responsiveness. https://app.cochat.ai/papers/10.1126/science.8248784
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- Bachmann, M. F., Rohrer, U. H., Kündig, T. M., Bürki, K., Hengartner, H., & Zinkernagel, R. M. (1993). The Influence of Antigen Organization on B Cell Responsiveness. Science. https://doi.org/10.1126/science.8248784
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
