The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Visualization of Single Molecules of RNA Polymerase Sliding Along DNA
Abstract
Transcription requires that RNA polymerase binds to promoters buried in nonspecific sites on DNA. The search for promoters may be facilitated if the polymerase slides along the molecule of DNA. Single molecules of Escherichia coli RNA polymerase were visualized, and their movements on immobilized bacteriophage λ and T7 DNAs were examined. Deviating from drifts by bulk flow, about 40 percent of the enzyme molecules moved along the extended DNA. The results provide direct evidence for sliding as a mechanism for relocation of the enzyme on DNA.
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Cites
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Cited by
Structure and Flexibility Adaptation in Nonspecific and Specific Protein-DNA Complexes
Kalodimos, C. G., Biris, N., Bonvin, A. M. J. J., Levandoski, M. M., Guennuegues, M., Boelens, R., & Kaptein, R. (2004) · Science · doi:10.1126/science.1097064 · Cited by 543
Probing Individual Molecules with Confocal Fluorescence Microscopy
Nie, S., Chiu, D. T., & Zare, R. N. (1994) · Science · doi:10.1126/science.7973650 · Cited by 549
Biological Physics of the Developing Embryo
Forgacs, G., & Newman, S. A. (2005) · doi:10.1017/cbo9780511755576 · Cited by 339
Fluctuation analysis of motor protein movement and single enzyme kinetics.
Svoboda, K., Mitra, P. P., & Block, S. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11782 · Cited by 294
Single-molecule imaging of RNA polymerase-DNA interactions in real time
Harada, Y., Funatsu, T., Murakami, K., Nonoyama, Y., Ishihama, A., & Yanagida, T. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77237-1 · Cited by 278
Metadata
- Authors
- Kabata, H., Kurosawa, O., Arai, I., Washizu, M., Margarson, S. A., Glass, R. E., & Shimamoto, N.
- Venue
- Science
- Published
- 1993-12-03
- Volume
- 262
- Issue
- 5139
- Pages
- 1561-1563
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2122295685
- Cited by
- 287
- References
- 1
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kabata, H., Kurosawa, O., Arai, I., Washizu, M., Margarson, S. A., Glass, R. E., & Shimamoto, N. (1993). Visualization of Single Molecules of RNA Polymerase Sliding Along DNA. Science. https://doi.org/10.1126/science.8248804
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
