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Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo
Abstract
During inflammation, neutrophils migrate from the vascular lumen into extravascular sites. In vitro assays have suggested that platelet-endothelial cell adhesion molecule-1 [PECAM-1 (CD31)], a member of the immunoglobulin superfamily, is required for the transmigration of neutrophils across endothelial monolayers. Antibody to human PECAM-1, which cross-reacts with rat PECAM-1, was found to block not only in vivo accumulation of rat neutrophils into the peritoneal cavity and the alveolar compartment of the lung but also neutrophil accumulation in human skin grafts transplanted onto immunodeficient mice. On the basis of these findings in three different models of inflammation, it appears that PECAM-1 is required for neutrophil transmigration in vivo and may thus be a potential therapeutic target.
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Citations
Cited by
Adhesion molecules and inflammatory injury
Albelda, S. M., Smith, C. W., & Ward, P. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.8.8181668 · Cited by 1,015
Self-citationC5a-induced expression of P-selectin in endothelial cells.
Foreman, K. E., Vaporciyan, A. A., Bonish, B. K., Jones, M. L., Johnson, K. J., Glovsky, M. M., Eddy, S. M., & Ward, P. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117430 · Cited by 473
Self-citationLeukocyte – endothelial interactions in inflammation
Langer, H. F., & Chavakis, T. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00811.x · Cited by 344
VE-cadherin antibody accelerates neutrophil recruitment in vivo
Gotsch, U., Borges, E., Bosse, R., Böggemeyer, E., Simon, M., Mossmann, H., & Vestweber, D. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.5.583 · Cited by 321
Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo.
Bogen, S., Pak, J., Garifallou, M., Deng, X., & Muller, W. A. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.3.1059 · Cited by 295
Metadata
- Authors
- Vaporciyan, A. A., DeLisser, H. M., Yan, H.-C., Mendiguren, I. I., Thom, S. R., Jones, M. L., Ward, P. A., & Albelda, S. M.
- Venue
- Science
- Published
- 1993-12-03
- Volume
- 262
- Issue
- 5139
- Pages
- 1580-1582
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049866297
- Cited by
- 458
- References
- 0
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo. https://app.cochat.ai/papers/10.1126/science.8248808
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- Vaporciyan, A. A., DeLisser, H. M., Yan, H.-C., Mendiguren, I. I., Thom, S. R., Jones, M. L., Ward, P. A., & Albelda, S. M. (1993). Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo. Science. https://doi.org/10.1126/science.8248808
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
