The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
VE-cadherin antibody accelerates neutrophil recruitment in vivo
Abstract
Neutrophils enter sites of inflammation by crossing the endothelial lining of the blood vessel wall. VE-cadherin is an endothelial specific, homophilic adhesion molecule located at the lateral cell surface. We have generated a monoclonal antibody against mouse VE-cadherin which inhibits electrical resistance of endothelial cell monolayers in vitro as well as aggregation of VE-cadherin transfected cells. In vivo, this antibody was found to increase vascular permeability and to accelerate the entry of neutrophils into chemically inflamed mouse peritoneum. Thus, VE-cadherin is essential for the integrity of the endothelial barrier in vivo. Our data suggest that opening of VE-cadherin mediated endothelial cell contacts may be a relevant step during neutrophil extravasation.
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Cites
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A novel endothelial-specific membrane protein is a marker of cell-cell contacts.
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Involvement of Platelet-Endothelial Cell Adhesion Molecule-1 in Neutrophil Recruitment in Vivo
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Cited by
How leukocytes cross the vascular endothelium
Vestweber, D. (2015) · Nature Reviews Immunology · doi:10.1038/nri3908 · Cited by 858
Self-citationOxidant stress and endothelial cell dysfunction
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Vestweber (2008) · doi:10.1161/atvbaha.107.158014 · Cited by 806
The blood-brain barrier in Alzheimer’s disease
Zenaro, E., Piacentino, G., & Constantin, G. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.07.007 · Cited by 767
Vascular endothelial–cadherin is an important determinant of microvascular integrity invivo
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Metadata
- Authors
- Gotsch, U., Borges, E., Bosse, R., Böggemeyer, E., Simon, M., Mossmann, H., & Vestweber, D.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1997-03-01
- Volume
- 110
- Issue
- 5
- Pages
- 583-588
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1915521129
- Cited by
- 321
- References
- 25
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: VE-cadherin antibody accelerates neutrophil recruitment in vivo. https://app.cochat.ai/papers/10.1242/jcs.110.5.583
- The paper
- Gotsch, U., Borges, E., Bosse, R., Böggemeyer, E., Simon, M., Mossmann, H., & Vestweber, D. (1997). VE-cadherin antibody accelerates neutrophil recruitment in vivo. Journal of Cell Science. https://doi.org/10.1242/jcs.110.5.583
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
