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Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor
Open accessAbstract
The interleukin-2 receptor γ chain (IL-2Rγ) is a necessary component of functional IL-2 receptors. IL-2Rγ mutations result in X-linked severe combined immunodeficiency (XSCID) in humans, a disease characterized by the presence of few or no T cells. In contrast, SCID patients with IL-2 deficiency and IL-2-deficient mice have normal numbers of T cells, suggesting that IL-2Rγ is part of more than one cytokine receptor. By using chemical cross-linking, IL-2Rγ was shown to be physically associated with the IL-7 receptor. The presence of IL-2Rγ augmented both IL-7 binding affinity and the efficiency of internalization of IL-7. These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common γ chain (gamma; c ) is proposed as the designation for IL-2Rγ.
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Cited by
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The IL-4 receptor: signaling mechanisms and biologic functions
Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545
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Ghoreschi, K., Laurence, A., & O’Shea, J. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00754.x · Cited by 1,149
An Interleukin-4-Induced Transcription Factor: IL-4 Stat
Hou, J., Schindler, U., Henzel, W. J., Ho, T. C., Brasseur, M., & McKnight, S. L. (1994) · Science · doi:10.1126/science.8085155 · Cited by 854
Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency
Puel, A., Ziegler, S. F., Buckley, R. H., & Leonard., W. J. (1998) · Nature Genetics · doi:10.1038/3877 · Cited by 813
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Metadata
- Authors
- Noguchi, M., Nakamura, Y., Russell, S. M., Ziegler, S. F., Tsang, M., Cao, X., & Leonard, W. J.
- Venue
- Science
- Published
- 1993-12-17
- Volume
- 262
- Issue
- 5141
- Pages
- 1877-1880
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084228983
- Cited by
- 1,109
- References
- 0
- FWCI
- 48.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Noguchi, M., Nakamura, Y., Russell, S. M., Ziegler, S. F., Tsang, M., Cao, X., & Leonard, W. J. (1993). Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor. Science. https://doi.org/10.1126/science.8266077
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