Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
Open accessAbstract
The existence of a common lymphoid progenitor that can only give rise to T cells, B cells, and natural killer (NK) cells remains controversial and constitutes an important gap in the hematopoietic lineage maps. Here, we report that the Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro. A single Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) cell could generate at least both T and B cells. These data provide direct evidence for the existence of common lymphoid progenitors in sites of early hematopoiesis.
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Only UMIs with at least 2 or more supporting reads were retained for final genotyping assignments.
“Only UMIs with at least 2 or more supporting reads were retained for final genotyping assignments, after the UMI collapse algorithm 42,86 .”
From Type 1 interferon perturbates clonal competition by reshaping human blood development (2026) · cites this paper as [86]
The paper’s Experimental Procedures (page unavailable) describe cell sorting and PCR to detect TCRβ and IgH rearrangements. Searches for UMIs, a UMI-collapse algorithm, and a two-read threshold found no passage addressing the claimed genotyping rule. (LLM, conf=0.76)
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Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L. (1990) · Cell · doi:10.1016/0092-8674(90)90262-d · Cited by 583 · see citing works
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- [1]1. Akashi, K. ∙ Weissman, I.L. The c-Kit+ maturation pathway in mouse thymic T cell developmentlineage and selection Immunity. 1996; 5:147-161 Full Text Full Text (PDF) Scopus (52) PubMed Google Scholar
- [2]2. Akashi, K. ∙ Harada, M. ∙ Shibuya, T. ... Simultaneous occurrence of myelomonocytic leukemia and multiple myelomainvolvement of common leukemic progenitors and their developmental abnormality of “lineage infidelity” J. Cell Physiol. 1991; 148:446-456 Crossref Scopus (34) PubMed Google Scholar
- [3]3. Akashi, K. ∙ Taniguchi, S. ∙ Nagafuji, K. ... B-lymphoid/myeloid stem cell origin in Ph-positive acute leukemia with myeloid markers Leuk. Res. 1993; 17:549-555 Crossref Scopus (20) PubMed Google Scholar
- [4]4. Akashi, K. ∙ Kondo, M. ∙ von Freeden-Jeffry, U. ... Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice Cell. 1997; 89:1033-1041 Full Text Full Text (PDF) Scopus (532) PubMed Google Scholar
- [5]5. Antica, M. ∙ Wu, L. ∙ Shortman, K. ... Thymic stem cells in mouse bone marrow Blood. 1994; 84:111-117 Crossref PubMed Google Scholar
- [6]6. Antin, J.H. ∙ Ferrara, J.L. Cytokine dysregulation and acute graft-versus-host disease Blood. 1992; 80:2964-2968 Crossref PubMed Google Scholar
- [7]7. Ardavin, C. ∙ Wu, L. ∙ Li, C.L. ... Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population Nature. 1993; 362:761-763 Crossref Scopus (585) PubMed Google Scholar
- [8]8. Cao, X. ∙ Shores, E.W. ∙ Hu-Li, J. ... Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain Immunity. 1995; 2:223-238
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Yan, M., Kanbe, E., Peterson, L. F., Boyapati, A., Miao, Y., Wang, Y., Chen, I.-M., Chen, Z., Rowley, J. D., Willman, C. L., et al. (2006) · Nature Medicine · doi:10.1038/nm1443 · Cited by 279 · see citing works
Anderson, M. K., Hernandez-Hoyos, G., Diamond, R. A., & Rothenberg, E. V. (1999) · Development · doi:10.1242/dev.126.14.3131 · Cited by 258 · see citing works
Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics · doi:10.1038/ng1679 · Cited by 237 · see citing works
Self-citationBiasco, L., Pellin, D., Scala, S., Dionisio, F., Basso-Ricci, L., Leonardelli, L., Scaramuzza, S., Baricordi, C., Ferrua, F., Cicalese, M. P., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.04.016 · Cited by 243 · see citing works
Miller, J. P., Izon, D., DeMuth, W., Gerstein, R., Bhandoola, A., & Allman, D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020784 · Cited by 198 · see citing works
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Porritt, H. E., Gordon, K., & Petrie, H. T. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030837 · Cited by 167 · see citing works
Balciunaite, G., Ceredig, R., & Rolink, A. G. (2005) · Blood · doi:10.1182/blood-2004-08-3087 · Cited by 158 · see citing works
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Schuringa, J. J., Chung, K. Y., Morrone, G., & Moore, M. A. S. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041024 · Cited by 140 · see citing works
Colucci, F., Samson, S. I., DeKoter, R. P., Lantz, O., Singh, H., & Di Santo, J. P. (2001) · Blood · doi:10.1182/blood.v97.9.2625 · Cited by 136 · see citing works
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Suh, H. C., Gooya, J., Renn, K., Friedman, A. D., Johnson, P. F., & Keller, J. R. (2006) · Blood · doi:10.1182/blood-2005-06-2216 · Cited by 95 · see citing works
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Carbonneau, C. L., Despars, G., Rojas-Sutterlin, S., Fortin, A., Le, O., Hoang, T., & Beauséjour, C. M. (2012) · Blood · doi:10.1182/blood-2011-06-361626 · Cited by 59 · see citing works
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Goldschneider, I. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00354.x · Cited by 51 · see citing works
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- Authors
- Kondo, M., Weissman, I. L., & Akashi, K.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Akashi, Koichi
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1997-11
- Volume
- 91
- Issue
- 5
- Pages
- 661-672
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2152414109
- Cited by
- 2,253
- References
- 1
- Citations by year
- 2026: 19 · 2025: 42 · 2024: 48 · 2023: 46 · 2022: 60 · 2021: 46 · 2020: 86 · 2019: 72 · 2018: 71 · 2017: 71 · 2016: 93 · 2015: 75 · 2014: 90 · 2013: 85 · 2012: 98
- FWCI
- 24.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ca042551-13)
- Stanford Bio-X
- National Cancer Institute (CA 42551)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- common lymphoid progenitors, clonogenic progenitors, T cell development, B cell development, natural killer cells, myeloid differentiation, hematopoietic lineage, early hematopoiesis, bone marrow, IL-7 receptor, Sca-1, KIT, CD90
- MeSH terms
- Animals, Antigens, Ly, B-Lymphocytes, Cell Differentiation, Clone Cells, Flow Cytometry, Hematopoietic Stem Cells, Indicator Dilution Techniques, Membrane Proteins, Methylcellulose, Mice, Inbred C57BL, T-Lymphocytes, Interleukin-7, Thy-1 Antigens, Proto-Oncogene Proteins c-kit, Mice
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