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Location of cAMP-Dependent Protein Kinase Type I with the TCR-CD3 Complex
Abstract
Selective activation of cyclic adenosine 3′,5′-monophosphate (cAMP)-dependent protein kinase type I (cAKI), but not type II, is sufficient to mediate inhibition of T cell replication induced through the antigen-specific T cell receptor-CD3 (TCR-CD3) complex. Immunocytochemistry and immunoprecipitation studies of the molecular mechanism by which cAKI inhibits TCR-CD3-dependent T cell replication demonstrated that regulatory subunit Iα, along with its associated kinase activity, translocated to and interacted with the TCR-CD3 complex during T cell activation and capping. Regulatory subunit IIα did not. When stimulated by cAMP, the cAKI localized to the TCR-CD3 complex may release kinase activity that, through phosphorylation, might uncouple the TCR-CD3 complex from intracellular signaling systems.
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Citations
Cited by
Skalhegg, B. (2000) · Frontiers in Bioscience · doi:10.2741/skalhegg · Cited by 482
Assembly of allosteric macromolecular switches: lessons from PKA
Taylor, S. S., Ilouz, R., Zhang, P., & Kornev, A. P. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3432 · Cited by 477
Physiological Substrates of cAMP-Dependent Protein Kinase
Shabb, J. B. (2001) · Chemical Reviews · doi:10.1021/cr000236l · Cited by 373
Epac and PKA: a tale of two intracellular cAMP receptors
Cheng, X., Ji, Z., Tsalkova, T., & Mei, F. (2008) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2008.00438.x · Cited by 340
Vang, T., Torgersen, K. M., Sundvold, V., Saxena, M., Levy, F. O., Skålhegg, B. S., Hansson, V., Mustelin, T., & Taskén, K. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.497 · Cited by 330
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Metadata
- Authors
- Skålhegg, B. S., Taskén, K., Hansson, V., Huitfeldt, H. S., Jahnsen, T., & Lea, T.
- Venue
- Science
- Published
- 1994-01-07
- Volume
- 263
- Issue
- 5143
- Pages
- 84-87
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027310516
- Cited by
- 196
- References
- 0
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Skålhegg, B. S., Taskén, K., Hansson, V., Huitfeldt, H. S., Jahnsen, T., & Lea, T. (1994). Location of cAMP-Dependent Protein Kinase Type I with the TCR-CD3 Complex. Science. https://doi.org/10.1126/science.8272870
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