The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Specificity in the cAMP/PKA signaling pathway. differential expression, regulation, and subcellular localization of subunits of PKA
Open accessAbstract
A large number of hormones, neurotransmitters and other signal substances utilize adenosine 3',5' cyclic monophosphate (cAMP) as an intracellular second messenger. Cyclic AMP regulates a number of different cellular processes such as cell growth and differentiation, ion channel conductivity, synaptic release of neurotransmitters, and gene transcription. The principle intracellular target for cAMP in mammalian cells is the cAMP-dependent protein kinase (PKA). The fact that this broad specificity protein kinase mediates a number of discrete physiological responses following cAMP-engagement, has raised the question of how specificity is maintained in the cAMP/PKA system. Here we will describe features of this signaling pathway that may contribute to explain how differential effects of cAMP may be contributed to features of the PKA signaling pathway.
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Targeting Adenosine in Cancer Immunotherapy to Enhance T-Cell Function
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Metadata
- Authors
- Skalhegg, B.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2000
- Volume
- 5
- Issue
- 1
- Pages
- d678
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- OpenAlex
- W4322388712
- Cited by
- 482
- References
- 64
- FWCI
- 6.20
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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