The DOI matches its Crossref record.
Structure of the Catalytic Domain of Fibroblast Collagenase Complexed with an Inhibitor
Abstract
Collagenase is a zinc-dependent endoproteinase and is a member of the matrix metalloproteinase (MMP) family of enzymes. The MMPs participate in connective tissue remodeling events and aberrant regulation has been associated with several pathologies. The 2.4 angstrom resolution structure of the inhibited enzyme revealed that, in addition to the catalytic zinc, there is a second zinc ion and a calcium ion which play a major role in stabilizing the tertiary structure of collagenase. Despite scant sequence homology, collagenase shares structural homology with two other endoproteinases, bacterial thermolysin and crayfish astacin. The detailed description of protein-inhibitor interactions present in the structure will aid in the design of compounds that selectively inhibit individual members of the MMP family. Such inhibitors will be useful in examining the function of MMPs in pathological processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Structure and function of matrix metalloproteinases and TIMPs
NAGASE, H., VISSE, R., & MURPHY, G. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.12.002 · Cited by 3,409
Structure and Function of Human Matrix Metalloproteinases
Laronha, H., & Caldeira, J. (2020) · Cells · doi:10.3390/cells9051076 · Cited by 609
Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor
McGeehan, G. M., Becherer, J. D., Bast, R. C., Boyer, C. M., Champion, B., Connolly, K. M., Conway, J. G., Furdon, P., Karp, S., Kidao, S., et al. (1994) · Nature · doi:10.1038/370558a0 · Cited by 561
Self-citationDiscovery of Potent Nonpeptide Inhibitors of Stromelysin Using SAR by NMR
Hajduk, P. J., Sheppard, G., Nettesheim, D. G., Olejniczak, E. T., Shuker, S. B., Meadows, R. P., Steinman, D. H., Carrera, G. M., Marcotte, P. A., Severin, J., et al. (1997) · Journal of the American Chemical Society · doi:10.1021/ja9702778 · Cited by 317
Llano, E., Adam, G., Pendás, A. M., Quesada, V., Sánchez, L. M., Santamarı́a, I., Noselli, S., & López-Otı́n, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200121200 · Cited by 100
Metadata
- Authors
- Lovejoy, B., Cleasby, A., Hassell, A. M., Longley, K., Luther, M. A., Weigl, D., McGeehan, G., McElroy, A. B., Drewry, D., Lambert, M. H., & Jordan, S. R.
- Venue
- Science
- Published
- 1994-01-21
- Volume
- 263
- Issue
- 5145
- Pages
- 375-377
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2159692814
- Cited by
- 328
- References
- 0
- FWCI
- 19.42
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Structure of the Catalytic Domain of Fibroblast Collagenase Complexed with an Inhibitor. https://app.cochat.ai/papers/10.1126/science.8278810
- The paper
- Lovejoy, B., Cleasby, A., Hassell, A. M., Longley, K., Luther, M. A., Weigl, D., McGeehan, G., McElroy, A. B., Drewry, D., Lambert, M. H., & Jordan, S. R. (1994). Structure of the Catalytic Domain of Fibroblast Collagenase Complexed with an Inhibitor. Science. https://doi.org/10.1126/science.8278810
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
