The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90)
Abstract
Assembled class I histocompatibility molecules, consisting of heavy chain, β 2 -microglobulin, and peptide ligand, are transported rapidly to the cell surface. In contrast, the intracellular transport of free heavy chains or peptide-deficient heavy chain-β 2 -microglobulin heterodimers is impaired. A 90-kilodalton membrane-bound chaperone of the endoplasmic reticulum (ER), termed calnexin, associates quantitatively with newly synthesized class I heavy chains, but the functions of calnexin in this interaction are unknown. Class I subunits were expressed alone or in combination with calnexin in Drosophila melanogaster cells. Calnexin retarded the intracellular transport of both peptide-deficient heavy chain-β 2 -microglobulin heterodimers and free heavy chains. Calnexin also impeded the rapid intracellular degradation of free heavy chains. The ability of calnexin to protect and retain class I assembly intermediates is likely to contribute to the efficient intracellular formation of class I-peptide complexes.
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Cites
Association of class I major histocompatibility heavy and light chains induced by viral peptides
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Selective and ATP-Dependent Translocation of Peptides by the MHC-Encoded Transporter
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Cited by
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Modeling water molecules in protein-ligand docking using GOLD.
Verdonk, M. L., Chessari, G., Cole, J. C., Hartshorn, M. J., Murray, C. W., Nissink, J. W. M., Taylor, R. D., & Taylor, R. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm050543p · Cited by 393
Regulation of transport of the dopamine D1 receptor by a new membrane-associated ER protein
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Metadata
- Authors
- Jackson, M. R., Cohen-Doyle, M. F., Peterson, P. A., & Williams, D. B.
- Venue
- Science
- Published
- 1994-01-21
- Volume
- 263
- Issue
- 5145
- Pages
- 384-387
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091797397
- Cited by
- 355
- References
- 27
- FWCI
- 18.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Jackson, M. R., Cohen-Doyle, M. F., Peterson, P. A., & Williams, D. B. (1994). Regulation of MHC Class I Transport by the Molecular Chaperone, Calnexin (p88, IP90). Science. https://doi.org/10.1126/science.8278813
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
