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Mortality Rates in a Genetically Heterogeneous Population of Caenorhabditis elegans
Abstract
Age-specific mortality rates in isogenic populations of the nematode Caenorhabditis elegans increase exponentially throughout life. In genetically heterogeneous populations, age-specific mortality increases exponentially until about 17 days and then remains constant until the last death occurs at about 60 days. This period of constant age-specific mortality results from genetic heterogeneity. Subpopulations differ in mean life-span, but they all exhibit near exponential, albeit different, rates of increase in age-specific mortality. Thus, much of the observed heterogeneity in mortality rates later in life could result from genetic heterogeneity and not from an inherent effect of aging.
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Cited by
The Reliability Theory of Aging and Longevity
GAVRILOV, L. A., & GAVRILOVA, N. S. (2001) · Journal of Theoretical Biology · doi:10.1006/jtbi.2001.2430 · Cited by 384
Hormones and the physiological architecture of life history evolution
Finch, C. E., & Rose, M. R. (1995) · The Quarterly Review of Biology · doi:10.1086/418864 · Cited by 376
Deceleration in the age pattern of mortality at olderages
Horiuchi, S., & Wilmoth, J. R. (1998) · Demography · doi:10.2307/3004009 · Cited by 289
Biological Implications of the Weibull and Gompertz Models of Aging
Ricklefs, R. E., & Scheuerlein, A. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.b69 · Cited by 125
Continuing the search for a law of mortality
Carnes, B. A., Olshansky, S. J., & Grahn, D. (1996) · Population and Development Review · doi:10.2307/2137434 · Cited by 88
Metadata
- Authors
- Brooks, A., Lithgow, G. J., & Johnson, T. E.
- Venue
- Science
- Published
- 1994-02-04
- Volume
- 263
- Issue
- 5147
- Pages
- 668-671
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977941460
- Cited by
- 172
- References
- 0
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brooks, A., Lithgow, G. J., & Johnson, T. E. (1994). Mortality Rates in a Genetically Heterogeneous Population of Caenorhabditis elegans. Science. https://doi.org/10.1126/science.8303273
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