The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antigenic Diversity and the Transmission Dynamics of Plasmodium falciparum
Abstract
The average age of humans at their first infection with Plasmodium falciparum is typically less than 1 year in most endemic areas. This has been interpreted as evidence of the high transmissibility of the parasite, with the implication that control of malaria will require high levels of coverage with a potential vaccine. This interpretation is challenged by mathematical models that demonstrate that the long period required to develop immunity to malaria permits a high risk (or low average age) of infection even when parasite transmissibility is low. Patterns of seroconversion to five antigenically distinct isolates of P. falciparum in a highly malarious area of Papua New Guinea indicate that each is only mildly transmissible and that malaria, as a construct of several such independently transmitted strains, has a basic reproductive rate (or transmissibility) that is an order of magnitude lower than other estimates.
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Citations
Cites
Rapid switching to multiple antigenic and adhesive phenotypes in malaria
Roberts, D. J., Craig, Berendt, A. R., Pinches, R., Nash, G., Marsh, K., & Newbold, C. I. (1992) · Nature · doi:10.1038/357689a0 · Cited by 619
Newbold, C. I., Pinches, R., Roberts, D. J., & Marsh, K. (1992) · Experimental Parasitology · doi:10.1016/0014-4894(92)90213-t · Cited by 144
Cited by
Bull, P. C., Lowe, B. S., Kortok, M., Molyneux, C. S., Newbold, C. I., & Marsh, K. (1998) · Nature Medicine · doi:10.1038/nm0398-358 · Cited by 645
Revisiting the Basic Reproductive Number for Malaria and Its Implications for Malaria Control
Smith, D. L., McKenzie, F. E., Snow, R. W., & Hay, S. I. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050042 · Cited by 466
The Epidemic Behavior of the Hepatitis C Virus
Pybus, O. G., Charleston, M. A., Gupta, S., Rambaut, A., Holmes, E. C., & Harvey, P. H. (2001) · Science · doi:10.1126/science.1058321 · Cited by 437
Self-citationChaos, Persistence, and Evolution of Strain Structure in Antigenically Diverse Infectious Agents
Gupta, S., Ferguson, N., & Anderson, R. (1998) · Science · doi:10.1126/science.280.5365.912 · Cited by 298
Self-citationAssociation of Malaria Parasite Population Structure, HLA, and Immunological Antagonism
Gilbert, S. C., Plebanski, M., Gupta, S., Morris, J., Cox, M., Aidoo, M., Kwiatkowski, D., Greenwood, B. M., Whittle, H. C., & Hill, A. V. S. (1998) · Science · doi:10.1126/science.279.5354.1173 · Cited by 279
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Metadata
- Authors
- Gupta, S., Trenholme, K., Anderson, R. M., & Day, K. P.
- Venue
- Science
- Published
- 1994-02-18
- Volume
- 263
- Issue
- 5149
- Pages
- 961-963
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013510734
- Cited by
- 199
- References
- 2
- FWCI
- 20.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gupta, S., Trenholme, K., Anderson, R. M., & Day, K. P. (1994). Antigenic Diversity and the Transmission Dynamics of Plasmodium falciparum. Science. https://doi.org/10.1126/science.8310293
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