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Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates
Abstract
Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The monoclonal antibody binds an antigen related to Lewis Y that is abundantly expressed at the surface of cells from many human carcinomas; it has a high degree of tumor selectivity and is internalized after binding. BR96-DOX induced complete regressions and cures of xenografted human lung, breast, and colon carcinomas growing subcutaneously in athymic mice and cured 70 percent of mice bearing extensive metastases of a human lung carcinoma. Also, BR96-DOX cured 94 percent of athymic rats with subcutaneous human lung carcinoma, even though the rats, like humans and in contrast to mice, expressed the BR96 target antigen in normal tissues.
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Cited by
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Antibody–Drug Conjugates: An Emerging Concept in Cancer Therapy
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Metadata
- Authors
- Trail, P. A., Willner, D., Lasch, S. J., Henderson, A. J., Hofstead, S., Casazza, A. M., Firestone, R. A., Hellström, I., & Hellström, K. E.
- Venue
- Science
- Published
- 1993-07-09
- Volume
- 261
- Issue
- 5118
- Pages
- 212-215
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2055642315
- Cited by
- 556
- References
- 0
- FWCI
- 47.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates. https://app.cochat.ai/papers/10.1126/science.8327892
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- Trail, P. A., Willner, D., Lasch, S. J., Henderson, A. J., Hofstead, S., Casazza, A. M., Firestone, R. A., Hellström, I., & Hellström, K. E. (1993). Cure of Xenografted Human Carcinomas by BR96-Doxorubicin Immunoconjugates. Science. https://doi.org/10.1126/science.8327892
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
