The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation
Abstract
The role of genetics in male sexual orientation was investigated by pedigree and linkage analyses on 114 families of homosexual men. Increased rates of same-sex orientation were found in the maternal uncles and male cousins of these subjects, but not in their fathers or paternal relatives, suggesting the possibility of sex-linked transmission in a portion of the population. DNA linkage analysis of a selected group of 40 families in which there were two gay brothers and no indication of nonmaternal transmission revealed a correlation between homosexual orientation and the inheritance of polymorphic markers on the X chromosome in approximately 64 percent of the sib-pairs tested. The linkage to markers on Xq28, the subtelomeric region of the long arm of the sex chromosome, had a multipoint lod score of 4.0 ( P = 10 -5 ), indicating a statistical confidence level of more than 99 percent that at least one subtype of male sexual orientation is genetically influenced.
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Cites
Steroid hormones as mediators of neural plasticity
McEwen, B. S., Coirini, H., Westlind-Danielsson, A., Frankfurt, M., Gould, E., Schumacher, M., & Woolley, C. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90067-f · Cited by 136
Cited by
A functional polymorphism in the monoamine oxidase A gene promoter
Sabol, S. Z., Hu, S., & Hamer, D. (1998) · Human Genetics · doi:10.1007/s004390050816 · Cited by 1,079
Self-citationLarge-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Ganna, A., Verweij, K. J. H., Nivard, M. G., Maier, R., Wedow, R., Busch, A. S., Abdellaoui, A., Guo, S., Sathirapongsasuti, J. F., 23andMe Research Team, et al. (2019) · Science · doi:10.1126/science.aat7693 · Cited by 406
Pedophilia and sexual offending against children: theory, assessment, and intervention
(2008) · Choice Reviews Online · doi:10.5860/choice.45-5272 · Cited by 374
Meyer-Bahlburg, H. F. L., Dolezal, C., Baker, S. W., & New, M. I. (2008) · Archives of Sexual Behavior · doi:10.1007/s10508-007-9265-1 · Cited by 326
Biological versus nonbiological older brothers and men’s sexual orientation
Bogaert, A. F. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511152103 · Cited by 238
Metadata
- Authors
- Hamer, D. H., Hu, S., Magnuson, V. L., Hu, N., & Pattatucci, A. M. L.
- Venue
- Science
- Published
- 1993-07-16
- Volume
- 261
- Issue
- 5119
- Pages
- 321-327
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035614594
- Cited by
- 871
- References
- 1
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamer, D. H., Hu, S., Magnuson, V. L., Hu, N., & Pattatucci, A. M. L. (1993). A Linkage Between DNA Markers on the X Chromosome and Male Sexual Orientation. Science. https://doi.org/10.1126/science.8332896
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
