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Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes
Abstract
Mice that bear the X-linked immunodeficiency ( xid ) mutation have a B lymphocyte-specific defect resulting in an inability to make antibody responses to polysaccharide antigens. A backcross of 1114 progeny revealed the colocalization of xid with Bruton's agammaglobulinemia tyrosine kinase ( btk ) gene, which is implicated in the human immune deficiency, X-linked agammaglobulinemia. Mice that carry xid have a missense mutation that alters a highly conserved arginine near the amino-terminus of the btk protein, Btk. Because this region of Btk lies outside any obvious kinase domain, the xid mutation may define another aspect of tyrosine kinase function.
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Citations
Cited by
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Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822
Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
THE HIGH-AFFINITY I g E RECEPTOR (FcεRI): From Physiology to Pathology
Kinet, J.-P. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.931 · Cited by 968
Role of Bruton’s tyrosine kinase in B cells and malignancies
Pal Singh, S., Dammeijer, F., & Hendriks, R. W. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0779-z · Cited by 726
Vidal, S., Tremblay, M. L., Govoni, G., Gauthier, S., Sebastiani, G., Malo, D., Skamene, E., Olivier, M., Jothy, S., & Gros, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.655 · Cited by 603
Metadata
- Authors
- Thomas, J. D., Sideras, P., Smith, C. I. E., Vořechovský, I., Chapman, V., & Paul, W. E.
- Venue
- Science
- Published
- 1993-07-16
- Volume
- 261
- Issue
- 5119
- Pages
- 355-358
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1966408108
- Cited by
- 613
- References
- 0
- FWCI
- 22.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thomas, J. D., Sideras, P., Smith, C. I. E., Vořechovský, I., Chapman, V., & Paul, W. E. (1993). Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes. Science. https://doi.org/10.1126/science.8332900
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
