The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Antisense Oligonucleotides as Therapeutic Agents—Is the Bullet Really Magical?
Abstract
Because of the specificity of Watson-Crick base pairing, attempts are now being made to use oligodeoxynucleotides (oligos) in the therapy of human disease. However, for a successful outcome, the oligo must meet at least six criteria: (i) the oligos can be synthesized easily and in bulk; (ii) the oligos must be stable in vivo; (iii) the oligos must be able to enter the target cell; (iv) the oligos must be retained by the target cell; (v) the oligos must be able to interact with their cellular targets; and (vi) the oligos should not interact in a non-sequence-specific manner with other macromolecules. Phosphorothioate oligos are examples of oligos that are being considered for clinical therapeutic trials and meet some, but not all, of these criteria. The potential use of phosphorothioate oligos as inhibitors of viral replication is highlighted.
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Cites
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
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Cited by
CpG motifs in bacterial DNA trigger direct B-cell activation
Krieg, A. M., Yi, A.-K., Matson, S., Waldschmidt, T. J., Bishop, G. A., Teasdale, R., Koretzky, G. A., & Klinman, D. M. (1995) · Nature · doi:10.1038/374546a0 · Cited by 3,508
A general purpose RNA-cleaving DNA enzyme
Santoro, S. W., & Joyce, G. F. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4262 · Cited by 1,541
Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes
Sugimoto, N., Nakano, S.-I., Katoh, M., Matsumura, A., Nakamuta, H., Ohmichi, T., Yoneyama, M., & Sasaki, M. (1995) · Biochemistry · doi:10.1021/bi00035a029 · Cited by 697
Mechanism and Utility of an RNA-Cleaving DNA Enzyme
Santoro, S. W., & Joyce, G. F. (1998) · Biochemistry · doi:10.1021/bi9812221 · Cited by 455
Li, D., & Mehta, J. L. (2000) · Circulation · doi:10.1161/01.cir.101.25.2889 · Cited by 421
Metadata
- Authors
- Stein, C. A., & Cheng, Y.-C.
- Venue
- Science
- Published
- 1993-08-20
- Volume
- 261
- Issue
- 5124
- Pages
- 1004-1012
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050014764
- Cited by
- 1,303
- References
- 2
- FWCI
- 47.59
- Type
- journal article
- Language
- en
- Open access
- closed
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