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A Role for the Transcription Factors Mbp1 and Swi4 in Progression from G1 to S Phase
Abstract
In budding yeast genes that encode G1 cyclins and proteins involved in DNA synthesis are transcriptionally activated in late G1. A transcription factor, called SBF, is composed of Swi4 and Swi6 proteins and activates transcription of G1 cyclin genes. A different, but related, complex called MBF binds to MCB elements (Mlu I cell cycle box) found in the promoter of most DNA synthesis genes. MBF contains Swi6 and a 120-kilodalton protein (p120). MBF was purified and the gene encoding p120 (termed MBP1 ) was cloned. A deletion of MBP1 was not lethal but led to deregulated expression of DNA synthesis genes, indicating a direct regulatory role for MBF in MCB-driven transcription. Mbp1 is related to Swi4. Strains deleted for both MBP1 and SWI4 were inviable, demonstrating that transcriptional activation by MBF and SBF has an important role in the transition from G1 to S phase.
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Cited by
Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF
Iyer, V. R., Horak, C. E., Scafe, C. S., Botstein, D., Snyder, M., & Brown, P. O. (2001) · Nature · doi:10.1038/35054095 · Cited by 1,083
Zhao, X., Muller, E. G. D., & Rothstein, R. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80277-4 · Cited by 728
Kinetic Analysis of a Molecular Model of the Budding Yeast Cell Cycle
Chen, K. C., Csikasz-Nagy, A., Gyorffy, B., Val, J., Novak, B., & Tyson, J. J. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.1.369 · Cited by 466
Mendenhall, M. D., & Hodge, A. E. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1191-1243.1998 · Cited by 429
FoxM1: At the crossroads of ageing and cancer
Laoukili, J., Stahl, M., & Medema, R. H. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.08.006 · Cited by 377
Metadata
- Authors
- Koch, C., Moll, T., Neuberg, M., Ahorn, H., & Nasmyth, K.
- Venue
- Science
- Published
- 1993-09-17
- Volume
- 261
- Issue
- 5128
- Pages
- 1551-1557
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2094923559
- Cited by
- 392
- References
- 0
- FWCI
- 9.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koch, C., Moll, T., Neuberg, M., Ahorn, H., & Nasmyth, K. (1993). A Role for the Transcription Factors Mbp1 and Swi4 in Progression from G1 to S Phase. Science. https://doi.org/10.1126/science.8372350
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