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Cited by 429

The DOI matches its Crossref record; 562 of the 562 references it cites were found in a registry or an index.

Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae

Open access
Mendenhall, Michael D., Hodge, Amy E.·1998·Microbiology and Molecular Biology Reviews

Abstract

SUMMARY: The cyclin-dependent protein kinase (CDK) encoded by CDC28 is the master regulator of cell division in the budding yeast Saccharomyces cerevisiae. By mechanisms that, for the most part, remain to be delineated, Cdc28 activity controls the timing of mitotic commitment, bud initiation, DNA replication, spindle formation, and chromosome separation. Environmental stimuli and progress through the cell cycle are monitored through checkpoint mechanisms that influence Cdc28 activity at key cell cycle stages. A vast body of information concerning how Cdc28 activity is timed and coordinated with various mitotic events has accrued. This article reviews that literature. Following an introduction to the properties of CDKs common to many eukaryotic species, the key influences on Cdc28 activity—cyclin-CKI binding and phosphorylation-dephosphorylation events—are examined. The processes controlling the abundance and activity of key Cdc28 regulators, especially transcriptional and proteolytic mechanisms, are then discussed in detail. Finally, the mechanisms by which environmental stimuli influence Cdc28 activity are summarized.

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Crossref · 10.1128/mmbr.62.4.1191-1243.1998

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Metadata

Authors
Mendenhall, M. D., & Hodge, A. E.
Venue
Microbiology and Molecular Biology Reviews
Published
1998-12
Volume
62
Issue
4
Pages
1191-1243
ISSN
  • 1092-2172 (ISSN-L)
  • 1098-5557
OpenAlex
W2160256138
Cited by
429
References
562
FWCI
0.95
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae. https://app.cochat.ai/papers/10.1128/mmbr.62.4.1191-1243.1998
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Mendenhall, M. D., & Hodge, A. E. (1998). Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae. Microbiology and Molecular Biology Reviews. https://doi.org/10.1128/mmbr.62.4.1191-1243.1998

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