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Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis
Abstract
Rheumatoid arthritis is an inflammatory synovial disease thought to involve T cells reacting to an antigen within the joint. Type II collagen is the major protein in articular cartilage and is a potential autoantigen in this disease. Oral tolerization to autoantigens suppresses animal models of T cell-mediated autoimmune disease, including two models of rheumatoid arthritis. In this randomized, double-blind trial involving 60 patients with severe, active rheumatoid arthritis, a decrease in the number of swollen joints and tender joints occurred in subjects fed chicken type II collagen for 3 months but not in those that received a placebo. Four patients in the collagen group had complete remission of the disease. No side effects were evident. These data demonstrate clinical efficacy of an oral tolerization approach for rheumatoid arthritis.
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Cited by
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des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
Advancing biomaterials of human origin for tissue engineering
Chen, F.-M., & Liu, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.02.004 · Cited by 1,158
Past, Present, and Future Technologies for Oral Delivery of Therapeutic Proteins
Singh, R., Singh, S., & Lillard, J. W. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21183 · Cited by 186
Lugo, J. P., Saiyed, Z. M., Lau, F. C., Molina, J. P. L., Pakdaman, M. N., Shamie, A. N., & Udani, J. K. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-48 · Cited by 82
Bioavailability and Bioavailable Forms of Collagen after Oral Administration to Rats
Wang, L., Wang, Q., Qian, J., Liang, Q., Wang, Z., Xu, J., He, S., & Ma, H. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5057502 · Cited by 53
Metadata
- Authors
- Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., & Weiner, H. L.
- Venue
- Science
- Published
- 1993-09-24
- Volume
- 261
- Issue
- 5129
- Pages
- 1727-1730
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2020317622
- Cited by
- 624
- References
- 0
- FWCI
- 45.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Trentham, D. E., Dynesius-Trentham, R. A., Orav, E. J., Combitchi, D., Lorenzo, C., Sewell, K. L., Hafler, D. A., & Weiner, H. L. (1993). Effects of Oral Administration of Type II Collagen on Rheumatoid Arthritis. Science. https://doi.org/10.1126/science.8378772
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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