Bioavailability and Bioavailable Forms of Collagen after Oral Administration to Rats
Abstract
The bioavailability and bioavailable forms of collagen after oral administration to rats were investigated in this study. The relative and absolute bioavailability of collagen were 57.8% and 49.6%, respectively, which was indirectly evaluated by the bioavailability of Hyp in collagen using a pharmacokinetic method. The amino acid profile of plasma showed that more than 63.4% of the collagen was absorbed from the intestine in the form of peptide, and there was a good linear correlation between the absorbed amount of an amino acid and its content in collagen (R(2) = 0.9225). The collagen peptides in plasma were purified by Sephadex G10 and Eclipse XDB C18 chromatography and further indentified (Ala-Asn, Ala-Hyp-Gly, Asp-Glu, Glu-Asn, Glu-Asp, Glu-Met, Gly-Pro-Hyp, Leu-Hyp, Leu-Met, Phe-Gly-Asn, Pro-Gly-Leu, Pro-Leu, Ser-Gly-Met, Ser-Hyp, Ser-Pro-Gly, Tyr-Met) with UPLC-ESI-MS. These results may help to speculate about the molecular mechanism behind the physiological effects of collagen after oral administration.
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Collagen is mainly absorbed and utilized in the form of peptides in mice, with a utilization rate of about 50%, while collagen peptides can be almost completely absorbed and utilized by the body.
“While collagen is mainly absorbed and utilized in the form of peptides in mice, with a utilization rate of about 50%, collagen peptides can be almost completely absorbed and utilized by the body [109].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [109]
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Diet and Skin Aging—From the Perspective of Food Nutrition
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- Authors
- Wang, L., Wang, Q., Qian, J., Liang, Q., Wang, Z., Xu, J., He, S., & Ma, H.
- Affiliations
- Jiangsu University (CN)
- Zhenjiang Kehua Aquaculture Development Company Limited, Zhenjiang 212134, People’s Republic of China
- Lianyungang Haideyi Food Company Limited, Lianyungang 222113, People’s Republic of China
- Corresponding author
- Wang, Lin
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-04-07
- Volume
- 63
- Issue
- 14
- Pages
- 3752-3756
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- OpenAlex
- W2032666892
- Cited by
- 53
- References
- 27
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 4 · 2015: 2
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Jiangsu Province (BK20140545)
- Science and Technology Support Program of Jiangsu Province (BE2014339)
- Zhenjiang City (NY2014023)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Life Sciences › Agricultural and Biological Sciences › Food Science › Proteins in Food Systems
- Keywords
- collagen, oral bioavailability, collagen peptides, hydroxyproline, intestinal peptide absorption, plasma amino acid profile, peptide identification, rats
- MeSH terms
- Amino Acid Sequence, Animals, Biological Availability, Collagen, Female, Molecular Sequence Data, Peptide Fragments, Mass Spectrometry, Rats, Sprague-Dawley, Rats
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