The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Cyclin-Dependent Regulation of G 1 in Mammalian Fibroblasts
Abstract
Eukaryotic cells become committed to proliferate during the G 1 phase of the cell cycle. In budding yeast, commitment occurs when the catalytic subunit of a protein kinase, encoded by the CDC28 gene (the homolog of the fission yeast cdc 2 + gene), binds to a positively acting regulatory subunit, a cyclin. Related kinases are also required for progression through the G 1 phase in higher eukaryotes. The role of cyclins in controlling G 1 progression in mammalian cells was tested by construction of fibroblasts that constitutively overexpress human cyclin E. This was found to shorten the duration of G 1 , decrease cell size, and diminish the serum requirement for the transition from G 1 to S phase. These observations show that cyclin levels can be rate-limiting for G 1 progression in mammalian cells and suggest that cyclin synthesis may be the target of physiological signals that control cell proliferation.
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Citations
Cites
Coordination of growth with cell division in the yeast
JOHNSTON, G., PRINGLE, J., & HARTWELL, L. (1977) · Experimental Cell Research · doi:10.1016/0014-4827(77)90154-9 · Cited by 827
Cited by
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
Wade Harper, J. (1993) · Cell · doi:10.1016/0092-8674(93)90499-g · Cited by 5,651
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
Role of insulin-like growth factors in embryonic and postnatal growth
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463
Polyak, K., Lee, M.-H., Erdjument-Bromage, H., Koff, A., Roberts, J. M., Tempst, P., & Massagué, J. (1994) · Cell · doi:10.1016/0092-8674(94)90572-x · Cited by 2,118
Self-citationDulić, V., Kaufmann, W. K., Wilson, S. J., Tisty, T. D., Lees, E., Harper, J. W., Elledge, S. J., & Reed, S. I. (1994) · Cell · doi:10.1016/0092-8674(94)90379-4 · Cited by 1,465
Metadata
- Authors
- Ohtsubo, M., & Roberts, J. M.
- Venue
- Science
- Published
- 1993-03-26
- Volume
- 259
- Issue
- 5103
- Pages
- 1908-1912
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1997643531
- Cited by
- 756
- References
- 1
- FWCI
- 35.83
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
