The DOI matches its Crossref record.
Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing
Abstract
Alternative splicing of precursor messenger RNAs (pre-mRNAs) is a common mechanism of regulating gene expression. SR proteins are a family of pre-mRNA splicing factors that are structurally related and evolutionarily conserved. Any member of the SR family can complement a splicing-deficient extract that lacks the entire family of SR proteins. Here it is demonstrated that particular SR proteins have distinct functions in alternative pre-mRNA splicing in vitro. In addition, SR proteins are differentially expressed in a variety of tissues. These results suggest a fundamental role for SR proteins in the regulation of alternative splicing.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Ceramide in apoptosis: an overview and current perspectives
Pettus, B. J., Chalfant, C. E., & Hannun, Y. A. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(02)00331-1 · Cited by 788
Birney, E., Kumar, S., & Krainer, A. R. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.25.5803 · Cited by 668
Chalfant, C. E., Rathman, K., Pinkerman, R. L., Wood, R. E., Obeid, L. M., Ogretmen, B., & Hannun, Y. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112010200 · Cited by 337
Sun, Q., Mayeda, A., Hampson, R. K., Krainer, A. R., & Rottman, F. M. (1993) · Genes & Development · doi:10.1101/gad.7.12b.2598 · Cited by 284
Calarco, J. A., Superina, S., O'Hanlon, D., Gabut, M., Raj, B., Pan, Q., Skalska, U., Clarke, L., Gelinas, D., van der Kooy, D., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.012 · Cited by 225
Metadata
- Authors
- Zahler, A. M., Neugebauer, K. M., Lane, W. S., & Roth, M. B.
- Venue
- Science
- Published
- 1993-04-09
- Volume
- 260
- Issue
- 5105
- Pages
- 219-222
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2013955971
- Cited by
- 405
- References
- 0
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing. https://app.cochat.ai/papers/10.1126/science.8385799
- The paper
- Zahler, A. M., Neugebauer, K. M., Lane, W. S., & Roth, M. B. (1993). Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing. Science. https://doi.org/10.1126/science.8385799
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
