The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer.
Open accessAbstract
The general splicing factor SF2/ASF binds in a sequence-specific manner to a purine-rich exonic splicing enhancer (ESE) in the last exon of bovine growth hormone (bGH) pre-mRNA. More importantly, SF2/ASF stimulates in vitro splicing of bGH intron D through specific interaction with the ESE sequences. However, another general splicing factor, SC35, does not bind the ESE sequences and has no effect on bGH intron D splicing. Thus, one possible function of SF2/ASF in alternative and, perhaps, constitutive pre-mRNA splicing is to recognize ESE sequences. The stimulation of bGH intron D splicing by SF2/ASF is counteracted by the addition of hnRNP A1. The relative levels of SF2/ASF and hnRNP A1 influence the efficiency of bGH intron D splicing in vitro and may be the underlying mechanism of this alternative pre-mRNA processing event in vivo.
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Cites
Dignam, J. D., Lebovitz, R. M., & Roeder, R. G. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.5.1475 · Cited by 11,260
SR proteins: a conserved family of pre-mRNA splicing factors.
Zahler, A. M., Lane, W. S., Stolk, J. A., & Roth, M. B. (1992) · Genes & Development · doi:10.1101/gad.6.5.837 · Cited by 798
Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2
Mayeda, A., & Krainer, A. R. (1992) · Cell · doi:10.1016/0092-8674(92)90477-t · Cited by 735
Self-citationExon definition may facilitate splice site selection in RNAs with multiple exons.
Robberson, B. L., Cote, G. J., & Berget, S. M. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.1.84 · Cited by 725
A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro
Ge, H., & Manley, J. L. (1990) · Cell · doi:10.1016/0092-8674(90)90236-8 · Cited by 477
A role for exon sequences and splice-site proximity in splice-site selection
Reed, R., & Maniatis, T. (1986) · Cell · doi:10.1016/0092-8674(86)90343-0 · Cited by 446
Krainer, A. R., Conway, G. C., & Kozak, D. (1990) · Cell · doi:10.1016/0092-8674(90)90237-9 · Cited by 444
Self-citationBoggs, R. T., Gregor, P., Idriss, S., Belote, J. M., & McKeown, M. (1987) · Cell · doi:10.1016/0092-8674(87)90332-1 · Cited by 413
Distinct Functions of SR Proteins in Alternative pre-mRNA Splicing
Zahler, A. M., Neugebauer, K. M., Lane, W. S., & Roth, M. B. (1993) · Science · doi:10.1126/science.8385799 · Cited by 405
The role of exon sequences in splice site selection.
Watakabe, A., Tanaka, K., & Shimura, Y. (1993) · Genes & Development · doi:10.1101/gad.7.3.407 · Cited by 361
Cited by
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216
An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN
Lorson, C. L. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.2.259 · Cited by 435
Metadata
- Authors
- Sun, Q., Mayeda, A., Hampson, R. K., Krainer, A. R., & Rottman, F. M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1993-12-01
- Volume
- 7
- Issue
- 12b
- Pages
- 2598-2608
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2156762274
- Cited by
- 284
- References
- 29
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Sun, Q., Mayeda, A., Hampson, R. K., Krainer, A. R., & Rottman, F. M. (1993). General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes & Development. https://doi.org/10.1101/gad.7.12b.2598
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
