The DOI matches its Crossref record.
Acceleration of Intracellular Calcium Waves in Xenopus Oocytes by Calcium Influx
Abstract
Many cell membrane receptors stimulate the phosphoinositide (PI) cycle, which produces complex intracellular calcium signals that regulate diverse processes such as secretion and transcription. A major messenger of this cycle, inositol 1,4,5-trisphosphate (IP 3 ), stimulates its receptor channel on the endoplasmic reticulum to release calcium into the cytosol. Activation of the PI cycle also induces calcium influx, which refills the intracellular calcium stores. Confocal microscopy was used to show that receptor-activated calcium influx, enhanced by hyperpolarization, modulates the frequency and velocity of IP 3 -dependent calcium waves in Xenopus laevis oocytes. These results demonstrate that transmembrane voltage and calcium influx pathways may regulate spatial and temporal patterns of IP 3 -dependent calcium release.
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Cited by
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Elementary and global aspects of calcium signalling.
Berridge, M. J. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021927 · Cited by 1,018
The Inositol Phosphate-Calcium Signaling System in Nonexcitable Cells
PUTNEY, J. W., & BIRD, G. S. J. (1993) · Endocrine Reviews · doi:10.1210/edrv-14-5-610 · Cited by 502
ter Keurs, H. E. D. J., & Boyden, P. A. (2007) · Physiological Reviews · doi:10.1152/physrev.00011.2006 · Cited by 356
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte
Atri, A., Amundson, J., Clapham, D., & Sneyd, J. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81191-3 · Cited by 344
Self-citation
Metadata
- Authors
- Girard, S., & Clapham, D.
- Venue
- Science
- Published
- 1993-04-09
- Volume
- 260
- Issue
- 5105
- Pages
- 229-232
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2052540730
- Cited by
- 167
- References
- 0
- FWCI
- 13.52
- Type
- journal article
- Language
- en
- Open access
- closed
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