Store-Operated Calcium Channels

Parekh, Anant B.; Putney, James W.

doi:10.1152/physrev.00057.2003

Cited by 2,089Ion Channels and ReceptorsCalcium signaling and nucleotide metabolismIon channel regulation and function

Store-Operated Calcium Channels

Parekh, Anant B., Putney, James W.·2005·Physiological Reviews

DOI 10.1152/physrev.00057.2003

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Abstract

In electrically nonexcitable cells, Ca 2+influx is essential for regulating a host of kinetically distinct processes involving exocytosis, enzyme control, gene regulation, cell growth and proliferation, and apoptosis. The major Ca 2+entry pathway in these cells is the store-operated one, in which the emptying of intracellular Ca 2+stores activates Ca 2+influx (store-operated Ca 2+entry, or capacitative Ca 2+entry). Several biophysically distinct store-operated currents have been reported, but the best characterized is the Ca 2+release-activated Ca 2+current, I CRAC. Although it was initially considered to function only in nonexcitable cells, growing evidence now points towards a central role for I CRAC-like currents in excitable cells too. In spite of intense research, the signal that relays the store Ca 2+content to CRAC channels in the plasma membrane, as well as the molecular identity of the Ca 2+sensor within the stores, remains elusive. Resolution of these issues would be greatly helped by the identification of the CRAC channel gene. In some systems, evidence suggests that store-operated channels might be related to TRP homologs, although no consensus has yet been reached. Better understood are mechanisms that inactivate store-operated entry and hence control the overall duration of Ca 2+entry. Recent work has revealed a central role for mitochondria in the regulation of I CRAC, and this is particularly prominent under physiological conditions. I CRAC therefore represents a dynamic interplay between endoplasmic reticulum, mitochondria, and plasma membrane. In this review, we describe the key electrophysiological features of I CRAC and other store-operated Ca 2+currents and how they are regulated, and we consider recent advances that have shed insight into the molecular mechanisms involved in this ubiquitous and vital Ca 2+entry pathway.

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The La3+-induced block of Ca2+ currents is a pharmacological hallmark of SOC channels.
“The La 3ϩ -induced block of Ca 2ϩ currents is a pharmacological hallmark of SOC channels (3, 4), further strengthening the functional similarity between CMC and SOC channels in mammalian cells.”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [4]
Unlike some SOC channels in higher eukaryotes that are highly permeable to Na+ in the absence of divalent cations, Cch1 is weakly permeable to Na+ and maintains strong Ca2+ selectivity even in high [Na+].
“These results indicated that unlike some SOC channels in higher eukaryotes that are highly permeable to Na ϩ in the absence of divalent cations, Cch1 is weakly permeable to Na ϩ and maintains a strong Ca 2ϩ selectivity even in the presence of high [Na ϩ ] (4, 27).”
From Cch1 Restores Intracellular Ca2+ in Fungal Cells during Endoplasmic Reticulum Stress (2010) · cites this paper as [4]

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Authors: Parekh, A. B., & Putney, J. W.
Affiliations: University of Oxford (GB)
National Institutes of Health (US)
ORCID: Parekh, Anant B.
Putney, James W.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2005-04
Volume: 85
Issue: 2
Pages: 757-810
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00057.2003
OpenAlex: W2137258759
Cited by: 2,089
References: 454
Citations by year: 2026: 18 · 2025: 30 · 2024: 25 · 2023: 38 · 2022: 55 · 2021: 67 · 2020: 67 · 2019: 69 · 2018: 80 · 2017: 90 · 2016: 96 · 2015: 108 · 2014: 120 · 2013: 111 · 2012: 137
FWCI: 13.85
Type: journal article
Language: en
Open access: closed
Locations: Physiological Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords: store-operated calcium entry, calcium release-activated calcium current, CRAC channels, intracellular calcium stores, endoplasmic reticulum, mitochondria, TRP channels, calcium signaling, non-excitable cells, excitable cells, calcium sensor, channel regulation
MeSH terms: Animals, Calcium, Disease, Electric Conductivity, Electrophysiology, Humans, Calcium Channels, Receptors, Calcium-Sensing

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