The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Reversible Binding of Nitric Oxide by a Salivary Heme Protein from a Bloodsucking Insect
Abstract
The bloodsucking bug Rhodnius prolixus has a salivary vasodilator, previously characterized as a nitrovasodilator, with salivary smooth muscle-relaxing and antiplatelet activity. Rhodnius salivary glands are bright red owing to the abundance of heme proteins. Electron paramagnetic resonance and optical spectroscopic experiments indicated that the salivary vasodilator is a nitrosylheme protein with an Fe(III) heme that binds nitric oxide (NO) reversibly. Dilution of the protein in neutral pH promoted NO release. This protein thus appears to be the NO carrier that helps R. prolixus to feed on blood.
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Cites
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Cited by
Nitric oxide and the immune response
Bogdan, C. (2001) · Nature Immunology · doi:10.1038/ni1001-907 · Cited by 3,447
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans
Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., & Stamler, J. S. (2001) · Nature · doi:10.1038/35068596 · Cited by 913
Role of Arthropod Saliva in Blood Feeding: Sialome and Post-Sialome Perspectives
Ribeiro, J. M. C., & Francischetti, I. M. B. (2003) · Annual Review of Entomology · doi:10.1146/annurev.ento.48.060402.102812 · Cited by 743
Self-citationMechanistic aspects of the reactions of nitric oxide with transition-metal complexes
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Metadata
- Authors
- Ribeiro, J. M. C., Hazzard, J. M. H., Nussenzveig, R. H., Champagne, D. E., & Walker, F. A.
- Venue
- Science
- Published
- 1993-04-23
- Volume
- 260
- Issue
- 5107
- Pages
- 539-541
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073141866
- Cited by
- 311
- References
- 10
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ribeiro, J. M. C., Hazzard, J. M. H., Nussenzveig, R. H., Champagne, D. E., & Walker, F. A. (1993). Reversible Binding of Nitric Oxide by a Salivary Heme Protein from a Bloodsucking Insect. Science. https://doi.org/10.1126/science.8386393
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
