The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Ryanodine Receptor Adaptation: Control Mechanism of Ca 2+ -Induced Ca 2+ Release in Heart
Abstract
Adaptation of single cardiac ryanodine receptor (RyR) channels was demonstrated by application of the caged calcium ion (Ca 2+ ) methodology. In contrast to conventional desensitization found in surface membrane ligand-gated channels, single cardiac RyR channels adapted to maintained Ca 2+ stimuli, preserving their ability to respond to a second (larger) Ca 2+ stimulus. RyR adaptation may represent a molecular control mechanism for smoothly graded Ca 2+ -induced Ca 2+ release in heart and may be a fundamental feature of channels, including the inositol trisphosphate receptor, that are involved in intracellular Ca 2+ signaling in many cell types.
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Cites
Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor
Takeshima, H., Nishimura, S., Matsumoto, T., Ishida, H., Kangawa, K., Minamino, N., Matsuo, H., Ueda, M., Hanaoka, M., Hirose, T., et al. (1989) · Nature · doi:10.1038/339439a0 · Cited by 1,146
Hormone-evoked calcium release from intracellular stores is a quantal process
Muallem, S., Pandol, S. J., & Beeker, T. G. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31244-9 · Cited by 307
Cited by
Cardiac excitation–contraction coupling
Bers, D. M. (2002) · Nature · doi:10.1038/415198a · Cited by 4,744
Microdomains of Intracellular Ca2+: Molecular Determinants and Functional Consequences
Rizzuto, R., & Pozzan, T. (2006) · Physiological Reviews · doi:10.1152/physrev.00004.2005 · Cited by 1,206
Calcium Fluxes Involved in Control of Cardiac Myocyte Contraction
Bers, D. M. (2000) · Circulation Research · doi:10.1161/01.res.87.4.275 · Cited by 580
Pieske, B., Maier, L. S., Bers, D. M., & Hasenfuss, G. (1999) · Circulation Research · doi:10.1161/01.res.85.1.38 · Cited by 369
Metadata
- Authors
- Györke, S., & Fill, M.
- Venue
- Science
- Published
- 1993-05-07
- Volume
- 260
- Issue
- 5109
- Pages
- 807-809
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1963851776
- Cited by
- 325
- References
- 2
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Györke, S., & Fill, M. (1993). Ryanodine Receptor Adaptation: Control Mechanism of Ca 2+ -Induced Ca 2+ Release in Heart. Science. https://doi.org/10.1126/science.8387229
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
