The DOI matches its Crossref record.
Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor
Abstract
Transforming growth factor-β (TGF-β) affects cellular proliferation, differentiation, and interaction with the extracellular matrix primarily through interaction with the type I and type II TGF-β receptors. The type II receptors for TGF-β and activin contain putative serine-threonine kinase domains. A murine serine-threonine kinase receptor, Tsk 7L, was cloned that shared a conserved extracellular domain with the type II TGF-β receptor. Overexpression of Tsk 7L alone did not increase cell surface binding of TGF-β, but coexpression with the type II TGF-β receptor caused TGF-β to bind to Tsk 7L, which had the size of the type I TGF-β receptor. Overexpression of Tsk 7L inhibited binding of TGF-β to the type II receptor in a dominant negative fashion. Combinatorial interactions and stoichiometric ratios between the type I and II receptors may therefore determine the extent of TGF-β binding and the resulting biological activities.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Wieser, R., Wrana, J. L., & Massagué, J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07214.x · Cited by 699
Activin Receptor-like Kinase (ALK)1 Is an Antagonistic Mediator of Lateral TGFβ/ALK5 Signaling
Goumans, M.-J., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., Karlsson, S., & ten Dijke, P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00386-1 · Cited by 689
Kloss, C. C., Lee, J., Zhang, A., Chen, F., Melenhorst, J. J., Lacey, S. F., Maus, M. V., Fraietta, J. A., Zhao, Y., & June, C. H. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.05.003 · Cited by 648
Parks, W. T., Frank, D. B., Huff, C., Renfrew Haft, C., Martin, J., Meng, X., de Caestecker, M. P., McNally, J. G., Reddi, A., Taylor, S. I., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100606200 · Cited by 113
Cowin, A. J., Hatzirodos, N., Holding, C. A., Dunaiski, V., Rayner, T. E., Harries, R. H., Fitridge, R., Cooter, R. D., Schultz, G. S., & Belford, D. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01501.x · Cited by 100
Metadata
- Authors
- Ebner, R., Chen, R.-H., Shum, L., Lawler, S., Zioncheck, T. F., Lee, A., Lopez, A. R., & Derynck, R.
- Venue
- Science
- Published
- 1993-05-28
- Volume
- 260
- Issue
- 5112
- Pages
- 1344-1348
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042480227
- Cited by
- 399
- References
- 0
- FWCI
- 22.86
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor. https://app.cochat.ai/papers/10.1126/science.8388127
- The paper
- Ebner, R., Chen, R.-H., Shum, L., Lawler, S., Zioncheck, T. F., Lee, A., Lopez, A. R., & Derynck, R. (1993). Cloning of a Type I TGF-β Receptor and Its Effect on TGF-β Binding to the Type II Receptor. Science. https://doi.org/10.1126/science.8388127
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
