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Sorting Nexin 6, a Novel SNX, Interacts with the Transforming Growth Factor-β Family of Receptor Serine-Threonine Kinases
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Several members of the sorting nexin family have been shown to interact with transmembrane receptors involved in cell signaling, in some cases via their carboxyl-terminal domain and in others via the PX domain.
“Several members of the sorting nexin family have been shown to interact with transmembrane receptors involved in cell signaling (8), in some cases via their carboxyl-terminal domain (23) and in others, via the PX domain (28).”
From Sorting Motifs in the Intracellular Domain of the Low Density Lipoprotein Receptor Interact with a Novel Domain of Sorting Nexin-17 (2004) · cites this paper as [28]
Certain sorting nexins (SNXs) are involved in receptor sorting and/or membrane trafficking.
“Prompted by recent findings that certain SNXs are involved in receptor sorting and/or membrane trafficking (Kurten et al ., 1996; Parks et al ., 2001; Xu et al ., 2001), we investigated whether the interaction of SNX17 with members of the LDLR family plays a role in the endocytic pathway of these receptors, and used the well characterized LDLR pathway for these studies.”
From The PX‐domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor (2002) · cites this paper as Parks et al., 2001
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The transforming growth factor-β superfamily of receptors
de Caestecker, M. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.004 · Cited by 464
Retromer: A Master Conductor of Endosome Sorting
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Proteomic identification of sorting nexin 6 as a negative regulator of BACE1‐mediated APP processing
Okada, H., Zhang, W., Peterhoff, C., Hwang, J. C., Nixon, R. A., Ryu, S. H., & Kim, T. (2010) · The FASEB Journal · doi:10.1096/fj.09-146357 · Cited by 102
Burden, J. J., Sun, X.-M., García, A. B. G., & Soutar, A. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313689200 · Cited by 82
Matters of context guide future research in TGFβ superfamily signaling
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Metadata
- Authors
- Parks, W. T., Frank, D. B., Huff, C., Renfrew Haft, C., Martin, J., Meng, X., de Caestecker, M. P., McNally, J. G., Reddi, A., Taylor, S. I., Roberts, A. B., Wang, T., & Lechleider, R. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 276
- Issue
- 22
- Pages
- 19332-19339
- ISSN
- 0021-9258
- Cited by
- 113
- References
- 2
- Language
- en
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