The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Subunit Identification and Reconstitution of the N-Type Ca 2+ Channel Complex Purified from Brain
Abstract
Calcium channels play an important role in regulating various neuronal processes, including synaptic transmission and cellular plasticity. The N-type calcium channels, which are sensitive to ω-conotoxin, are involved in the control of transmitter release from neurons. A functional N-type calcium channel complex was purified from rabbit brain. The channel consists of a 230-kilodalton subunit (α 1B ) that is tightly associated with a 160-kilodalton subunit (α 2 δ), a 57-kilodalton subunit (β 3 ), and a 95-kilodalton glycoprotein subunit. The complex formed a functional calcium channel with the same pharmacological properties and conductance as those of the native ω-conotoxin-sensitive calcium channel in neurons.
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Cites
Multiple types of neuronal calcium channels and their selective modulation
Tsien, R. W., Lipscombe, D., Madison, D. V., Bley, K. R., & Fox, A. P. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90194-4 · Cited by 1,381
Cited by
Structure and Regulation of Voltage-Gated Ca 2+ Channels
Catterall, W. A. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.521 · Cited by 2,344
Calcium Absorption Across Epithelia
Hoenderop, J. G. J., Nilius, B., & Bindels, R. J. M. (2005) · Physiological Reviews · doi:10.1152/physrev.00003.2004 · Cited by 936
Exocytotic Ca2+ channels in mammalian central neurons
Dunlap, K., Luebke, J. I., & Turner, T. J. (1995) · Trends in Neurosciences · doi:10.1016/0166-2236(95)80030-6 · Cited by 915
Structure and function of neuronal Ca2+ channels and their role in neurotransmitter release
Catterall, W. A. (1998) · Cell Calcium · doi:10.1016/s0143-4160(98)90055-0 · Cited by 386
Bichet, D., Cornet, V., Geib, S., Carlier, E., Volsen, S., Hoshi, T., Mori, Y., & De Waard, M. (2000) · Neuron · doi:10.1016/s0896-6273(00)80881-8 · Cited by 377
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Metadata
- Authors
- Witcher, D. R., De Waard, M., Sakamoto, J., Franzini-Armstrong, C., Pragnell, M., Kahl, S. D., & Campbell, K. P.
- Venue
- Science
- Published
- 1993-07-23
- Volume
- 261
- Issue
- 5120
- Pages
- 486-489
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2089543949
- Cited by
- 248
- References
- 1
- FWCI
- 10.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Witcher, D. R., De Waard, M., Sakamoto, J., Franzini-Armstrong, C., Pragnell, M., Kahl, S. D., & Campbell, K. P. (1993). Subunit Identification and Reconstitution of the N-Type Ca 2+ Channel Complex Purified from Brain. Science. https://doi.org/10.1126/science.8392754
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
