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Optical Time-of-Flight and Absorbance Imaging of Biologic Media
Abstract
Imaging the interior of living bodies with light may assist in the diagnosis and treatment of a number of clinical problems, which include the early detection of tumors and hypoxic cerebral injury. An existing picosecond time-of-flight and absorbance (TOFA) optical system has been used to image a model biologic system and a rat. Model measurements confirmed TOFA principles in systems with a high degree of photon scattering; rat images, which were constructed from the variable time delays experienced by a fixed fraction of early-arriving transmitted photons, revealed identifiable internal structure. A combination of light-based quantitative measurement and TOFA localization may have applications in continuous, noninvasive monitoring for structural imaging and spatial chemometric analysis in humans.
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Citations
Cited by
Imaging with terahertz radiation
Chan, W. L., Deibel, J., & Mittleman, D. M. (2007) · Reports on Progress in Physics · doi:10.1088/0034-4885/70/8/r02 · Cited by 965
Spectroscopy and Imaging with Diffusing Light
Yodh, A., & Chance, B. (1995) · Physics Today · doi:10.1063/1.881445 · Cited by 800
Matcher, S. J., Cope, M., & Delpy, D. T. (1994) · Physics in Medicine and Biology · doi:10.1088/0031-9155/39/1/011 · Cited by 323
Metadata
- Authors
- Benaron, D. A., & Stevenson, D. K.
- Venue
- Science
- Published
- 1993-03-05
- Volume
- 259
- Issue
- 5100
- Pages
- 1463-1466
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050756936
- Cited by
- 230
- References
- 0
- FWCI
- 21.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Benaron, D. A., & Stevenson, D. K. (1993). Optical Time-of-Flight and Absorbance Imaging of Biologic Media. Science. https://doi.org/10.1126/science.8451643
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