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Similarity of the Yeast RAD51 Filament to the Bacterial RecA Filament
Abstract
The RAD51 protein functions in the processes of DNA repair and in mitotic and meiotic genetic recombination in the yeast Saccharomyces cerevisiae . The protein has adenosine triphosphate-dependent DNA binding activities similar to those of the Escherichia coli RecA protein, and the two proteins have 30 percent sequence homology. RAD51 polymerized on double-stranded DNA to form a helical filament nearly identical in low-resolution, three-dimensional structure to that formed by RecA. Like RecA, RAD51 also appears to force DNA into a conformation of approximately a 5.1-angstrom rise per base pair and 18.6 base pairs per turn. As in other protein families, its structural conservation appears to be stronger than its sequence conservation. Both the structure of the protein polymer formed by RecA and the DNA conformation induced by RecA appear to be general properties of a class of recombination proteins found in prokaryotes as well as eukaryotes.
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Cited by
Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae
Pâques, F., & Haber, J. E. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.349-404.1999 · Cited by 2,120
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex
Pellegrini, L., Yu, D. S., Lo, T., Anand, S., Lee, M., Blundell, T. L., & Venkitaraman, A. R. (2002) · Nature · doi:10.1038/nature01230 · Cited by 704
Sung, P. (1997) · Genes & Development · doi:10.1101/gad.11.9.1111 · Cited by 540
Regulation of Bacterial RecA Protein Function
Cox, M. M. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701260258 · Cited by 417
Recombination at Double-Strand Breaks and DNA Ends
Cromie, G. A., Connelly, J. C., & Leach, D. R. F. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00419-1 · Cited by 325
Metadata
- Authors
- Ogawa, T., Yu, X., Shinohara, A., & Egelman, E. H.
- Venue
- Science
- Published
- 1993-03-26
- Volume
- 259
- Issue
- 5103
- Pages
- 1896-1899
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2028084970
- Cited by
- 670
- References
- 0
- FWCI
- 13.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ogawa, T., Yu, X., Shinohara, A., & Egelman, E. H. (1993). Similarity of the Yeast RAD51 Filament to the Bacterial RecA Filament. Science. https://doi.org/10.1126/science.8456314
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