The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Molecular Mechanism of Transcription-Repair Coupling
Abstract
Lesions in the transcribed strand block transcription and are repaired more rapidly than lesions in the nontranscribed (coding) strand which do not block RNA polymerase (RNAP). It has been shown previously that in Escherichia coli the mfd (mutation frequency decline) gene is necessary for strand-specific repair. The mfd gene was cloned and sequenced and the Mfd protein was purified and used to reconstitute strand-specific repair in a completely defined system. The mfd gene encodes a protein of 130 kilodaltons and contains the so-called "helicase motifs," a leucine zipper motif, and regions of sequence similarity to UvrB and RecG proteins. The Mfd protein was shown to (i) displace RNAP stalled at a lesion in an adenosine triphosphate-dependent reaction, (ii) bind to the damage recognition subunit (UvrA) of the excision nuclease, and (iii) stimulate the repair of the transcribed strand only when transcription is taking place. Thus, Mfd appears to target the transcribed strand for repair by recognizing a stalled RNAP and actively recruiting the repair enzyme to the transcription blocking lesion as it dissociates the stalled RNAP.
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Cites
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Cited by
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
Sancar, A., Lindsey-Boltz, L. A., Ünsal-Kaçmaz, K., & Linn, S. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073723 · Cited by 3,317
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Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions
Eisen, J. A., Sweder, K. S., & Hanawalt, P. C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.14.2715 · Cited by 717
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.
Chen, Q., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4130 · Cited by 641
Paulovich, A. G., & Hartwell, L. H. (1995) · Cell · doi:10.1016/0092-8674(95)90481-6 · Cited by 588
Metadata
- Authors
- Selby, C. P., & Sancar, A.
- Venue
- Science
- Published
- 1993-04-02
- Volume
- 260
- Issue
- 5104
- Pages
- 53-58
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2049353359
- Cited by
- 656
- References
- 34
- FWCI
- 18.49
- Type
- journal article
- Language
- en
- Open access
- closed
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