The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Reversal of Left-Right Asymmetry: a Situs Inversus Mutation
Abstract
A recessive mutation was identified in a family of transgenic mice that resulted in a reversal of left-right polarity (situs inversus) in 100 percent of the homozygous transgenic mice tested. Sequences that flanked the transgenic integration site were cloned and mapped to mouse chromosome 4, between the Tsha and Hxb loci. During early embryonic development, the direction of postimplantation turning, one of the earliest manifestations of left-right asymmetry, was reversed in homozygous transgenic embryos. This insertional mutation identifies a gene that controls embryonic turning and visceral left-right polarity.
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Citations
Cites
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Self-citationDevelopment and applications of a molecular genetic linkage map of the mouse genome
Copeland, N. (1991) · Trends in Genetics · doi:10.1016/0168-9525(91)90085-5 · Cited by 440
Self-citationThe development of handedness in left/right asymmetry
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Random determination of a developmental process: Reversal of normal visceral asymmetry in the mouse
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Cited by
Protein Radicals in Enzyme Catalysis
Stubbe, J., & van der Donk, W. A. (1998) · Chemical Reviews · doi:10.1021/cr9400875 · Cited by 1,377
The Ciliopathies: An Emerging Class of Human Genetic Disorders
Badano, J. L., Mitsuma, N., Beales, P. L., & Katsanis, N. (2006) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.7.080505.115610 · Cited by 1,144
Ciliopathies: an expanding disease spectrum
Waters, A. M., & Beales, P. L. (2011) · Pediatric Nephrology · doi:10.1007/s00467-010-1731-7 · Cited by 676
Relationship between asymmetric nodal expression and the direction of embryonic turning
Collignon, J., Varlet, I., & Robertson, E. J. (1996) · Nature · doi:10.1038/381155a0 · Cited by 561
Establishment of vertebrate left–right asymmetry
Hamada, H., Meno, C., Watanabe, D., & Saijoh, Y. (2002) · Nature Reviews Genetics · doi:10.1038/nrg732 · Cited by 489
Metadata
- Authors
- Yokoyama, T., Copeland, N. G., Jenkins, N. A., Montgomery, C. A., Elder, F. F. B., & Overbeek, P. A.
- Venue
- Science
- Published
- 1993-04-30
- Volume
- 260
- Issue
- 5108
- Pages
- 679-682
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1988977149
- Cited by
- 462
- References
- 16
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yokoyama, T., Copeland, N. G., Jenkins, N. A., Montgomery, C. A., Elder, F. F. B., & Overbeek, P. A. (1993). Reversal of Left-Right Asymmetry: a Situs Inversus Mutation. Science. https://doi.org/10.1126/science.8480178
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
