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Establishment of vertebrate left–right asymmetry

Hamada, Hiroshi, Meno, Chikara, Watanabe, Daisuke, Saijoh, Yukio·2002·Nature Reviews Genetics
DOI 10.1038/nrg732
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Abstract

The generation of morphological, such as left-right, asymmetry during development is an integral part of the establishment of a body plan. Until recently, the molecular basis of left-right asymmetry was a mystery, but studies indicate that Nodal and the Lefty proteins, transforming growth factor-beta-related molecules, have a central role in generating asymmetric signals. Although the initial mechanism of symmetry breaking remains unknown, developmental biologists are beginning to analyse the pathway that leads to left-right asymmetry establishment and maintenance.

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Authors
Hamada, H., Meno, C., Watanabe, D., & Saijoh, Y.
Venue
Nature Reviews Genetics
Publisher
Springer Science and Business Media LLC
Published
2002-02
Volume
3
Issue
2
Pages
103-113
ISSN
  • 1471-0056
  • 1471-0064
DOI
10.1038/nrg732
Cited by
489
References
1
Language
en
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