The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Tyrosine Kinase-Stimulated Guanine Nucleotide Exchange Activity of Vav in T Cell Activation
Abstract
The hematopoietically expressed product of the vav proto-oncogene, Vav, shares homology with guanine nucleotide releasing factors (GRFs) [also called guanosine diphosphate-dissociation stimulators (GDSs)] that activate Ras-related small guanosine triphosphate (GTP)-binding proteins. Human T cell lysates or Vav immunoprecipitates possessed GRF activity that increased after T cell antigen receptor (TCR)-CD3 triggering; an in vitro-translated Vav fragment that contained the putative GRF domain was also active. Vav-associated GRF stimulation after TCR-CD3 ligation paralleled its tyrosine phosphorylation; both were blocked by a protein tyrosine kinase (PTK) inhibitor. Vav also was a substrate for the p56 lck PTK. Thus, Vav is a PTK-regulated GRF that may be important in TCR-CD3-initiated signal transduction through the activation of Ras.
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Cites
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants
Trahey, M., & McCormick, F. (1987) · Science · doi:10.1126/science.2821624 · Cited by 1,211
Cited by
Cerione, R. A., & Zheng, Y. (1996) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(96)80068-8 · Cited by 437
Damen, J., Liu, L., Cutler, R., & Krystal, G. (1993) · Blood · doi:10.1182/blood.v82.8.2296.2296 · Cited by 193
Seipel, K., Medley, Q. G., Kedersha, N. L., Zhang, X. A., O’Brien, S. P., Serra-Pages, C., Hemler, M. E., & Streuli, M. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.12.1825 · Cited by 62
Metadata
- Authors
- Gulbins, E., Coggeshall, K. M., Baier, G., Katzav, S., Burn, P., & Altman, A.
- Venue
- Science
- Published
- 1993-05-07
- Volume
- 260
- Issue
- 5109
- Pages
- 822-825
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986543124
- Cited by
- 274
- References
- 2
- FWCI
- 21.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Gulbins, E., Coggeshall, K. M., Baier, G., Katzav, S., Burn, P., & Altman, A. (1993). Tyrosine Kinase-Stimulated Guanine Nucleotide Exchange Activity of Vav in T Cell Activation. Science. https://doi.org/10.1126/science.8484124
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